Escape from nonsense-mediated decay associates with anti-tumor immunogenicity
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DOI: 10.1038/s41467-020-17526-5
Abstract: Frameshift insertion/deletions (fs-indels) are an infrequent but highly immunogenic mutation subtype. Although fs-indels are degraded through the nonsense-mediated decay (NMD) pathway, we hypothesise that some fs-indels escape degradation and elicit anti-tumor immune responses. Using allele-specific… read more here.
Keywords: escape; mediated decay; nmd escape; anti tumor ... See more keywords