Alleviation by GABAB Receptors of Neurotoxicity Mediated by Mitochondrial Permeability Transition Pore in Cultured Murine Cortical Neurons Exposed to N-Methyl-d-aspartate
Sign Up to like & getrecommendations! Published in 2017 at "Neurochemical Research"
DOI: 10.1007/s11064-017-2311-z
Abstract: Mitochondrial permeability transition pore (PTP) is supposed to at least in part participate in molecular mechanisms underlying the neurotoxicity seen after overactivation of N-methyl-d-aspartate (NMDA) receptor (NMDAR) in neurons. In this study, we have evaluated… read more here.
Keywords: methyl aspartate; nmda; neurotoxicity; mitochondrial permeability ... See more keywords
Involvement of matrix metalloproteinases in capillary degeneration following NMDA‐induced neurotoxicity in the neonatal rat retina
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Eye Research"
DOI: 10.1016/j.exer.2019.03.005
Abstract: Abstract Interactions between neuronal cells and vascular cells in the retina are critical for maintaining retinal tissue homeostasis. Impairment of cellular interactions contributes to development and progression of retinal diseases. Previous studies demonstrated that neuronal… read more here.
Keywords: capillary degeneration; mmp; nmda; neurovascular degeneration ... See more keywords
Inhibition of Hint1 Modulates Spinal Nociception and NMDA Evoked Behavior in Mice.
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DOI: 10.1021/acschemneuro.9b00432
Abstract: The interactions between the mu-opioid (MOR) and N-methyl-D-aspartate receptor (NMDAR) constitute an area of intense investigation due to their contributions to maladaptive neuroplasticity. Recent evidence suggests that their association requires the involvement of histidine triad… read more here.
Keywords: tolerance; hint1; nmda; receptor ... See more keywords
A New Rat Model of Epileptic Spasms Based on Methylazoxymethanol-Induced Malformations of Cortical Development
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DOI: 10.3389/fneur.2017.00271
Abstract: Malformations of cortical development (MCDs) can cause medically intractable epilepsies and cognitive disabilities in children. We developed a new model of MCD-associated epileptic spasms by treating rats prenatally with methylazoxymethanol acetate (MAM) to induce cortical… read more here.
Keywords: cortical development; epileptic spasms; malformations cortical; nmda ... See more keywords
Synaptic Dysfunction by Mutations in GRIN2B: Influence of Triheteromeric NMDA Receptors on Gain-of-Function and Loss-of-Function Mutant Classification
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DOI: 10.3390/brainsci12060789
Abstract: GRIN2B mutations are rare but often associated with patients having severe neurodevelopmental disorders with varying range of symptoms such as intellectual disability, developmental delay and epilepsy. Patient symptoms likely arise from mutations disturbing the role… read more here.
Keywords: glun2b; nmda; function; gof ... See more keywords