Antiapoptotic effect of taurine against NMDA‐induced retinal excitotoxicity in rats
Sign Up to like & getrecommendations! Published in 2019 at "Neurotoxicology"
DOI: 10.1016/j.neuro.2018.10.009
Abstract: Objective: N‐methyl‐D‐aspartate (NMDA) excitotoxicity has been proposed to mediate apoptosis of retinal ganglion cells (RGCs) in glaucoma. Taurine (TAU) has been shown to have neuroprotective properties, thus we examined anti‐apoptotic effect of TAU against retinal… read more here.
Keywords: tau; nmda induced; treatment; group ... See more keywords
Deletion of the Na/HCO3 Transporter NBCn1 Protects Hippocampal Neurons from NMDA-induced Seizures and Neurotoxicity in Mice
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-52413-0
Abstract: The Na/HCO3 cotransporter NBCn1/SLC4A7 can affect glutamate neurotoxicity in primary cultures of rat hippocampal neurons. Here, we examined NMDA-induced neurotoxicity in NBCn1 knockout mice to determine whether a similar effect also occurs in the mouse… read more here.
Keywords: hippocampal neurons; nmda induced; transporter nbcn1; hco3 transporter ... See more keywords
Polyphosphoric acid-promoted one-pot synthesis and neuroprotective effects of flavanones against NMDA-induced injury in PC12 cells
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DOI: 10.1039/d2ra03562f
Abstract: We report herein an efficient polyphosphoric acid (PPA) promoted one-pot protocol for the synthesis of flavanone derivatives from 2-hydroxyacetophenones and benzaldehydes. A variety of flavanones were produced in moderate to excellent yields and evaluated for… read more here.
Keywords: polyphosphoric acid; neuroprotective effects; nmda induced; one pot ... See more keywords
Regulatory role of hippocampal PI3K and mTOR signaling pathway in NMDA-induced infant spasm rats
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DOI: 10.1080/01616412.2019.1672412
Abstract: ABSTRACT Objectives: To explore the role of mTOR signaling pathway in modulating epileptogenesis in an N-methyl-D-aspartic acid (NMDA)-induced infant spasm (IS) rat model. Methods: After inducing IS successfully, the phosphorylation status of PI3K, Akt, mTOR… read more here.
Keywords: pi3k; pi3k mtor; nmda induced; mtor signaling ... See more keywords
Intravitreal Trans-Resveratrol Ameliorates NMDA-Induced Optic Nerve and Retinal Injury
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DOI: 10.1080/02713683.2022.2033270
Abstract: Abstract Purpose Retinal and optic nerve damage in glaucoma involves excitotoxicity via N-methyl-D-aspartate (NMDA) receptors. Since, trans-resveratrol (TR) is known to provide neuroprotection, we investigated its protective effects against NMDA-induced retinal and optic nerve injury.… read more here.
Keywords: optic nerve; nmda induced; retinal optic; nerve ... See more keywords
Signaling pathways involved in NMDA‐induced suppression of M‐channels in corticotropin‐releasing hormone neurons in central amygdala
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.15647
Abstract: Glutamate N‐methyl‐d‐aspartate (NMDA) receptors (NMDARs) and Kv7/M channels are importantly involved in regulating neuronal activity involved in various physiological and pathological functions. Corticotropin‐releasing hormone (CRH)‐expressing neurons in the central nucleus of the amygdala (CeA) critically… read more here.
Keywords: releasing hormone; induced suppression; nmda induced; corticotropin releasing ... See more keywords
An Epilepsy-Associated Mutation of Salt-Inducible Kinase 1 Increases the Susceptibility to Epileptic Seizures and Interferes with Adrenocorticotropic Hormone Therapy for Infantile Spasms in Mice
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23147927
Abstract: Six mutations in the salt-inducible kinase 1 (SIK1) have been identified in developmental and epileptic encephalopathy (DEE-30) patients, and two of the mutations are nonsense mutations that truncate the C-terminal region of SIK1. In a… read more here.
Keywords: salt inducible; nmda induced; epileptic seizures; sik1 ... See more keywords
Design, Synthesis, and Biological Evaluation of Novel Tomentosin Derivatives in NMDA-Induced Excitotoxicity
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DOI: 10.3390/ph15040421
Abstract: N-methyl-D-aspartate (NMDA) receptor stimulation may lead to excitotoxicity, which triggers neuronal death in brain disorders. In addition to current clinical therapeutic approaches, treatment strategies by phytochemicals or their derivatives are under investigation for neurodegenerative diseases.… read more here.
Keywords: tomentosin derivatives; nmda induced; novel; excitotoxicity ... See more keywords