GluN2A‐Selective NMDA Receptor Antagonists: Mimicking the U‐Shaped Bioactive Conformation of TCN‐201 by a [2.2]Paracyclophane System
Sign Up to like & getrecommendations! Published in 2022 at "Chemmedchem"
DOI: 10.1002/cmdc.202200484
Abstract: Under physiological conditions, N‐Methyl‐D‐Aspartate (NMDA) receptors play a crucial role for synaptic plasticity, long‐term potentiation and long‐term depression. However, overactivation of NMDA receptors can result in excitotoxicity, which is associated with various neurological and neurodegenerative… read more here.
Keywords: nmda receptor; tcn 201; receptor antagonists; selective nmda ... See more keywords
New onset metabolic derangement in a pediatric patient receiving therapeutic plasma exchange for anti‐NMDA receptor encephalitis
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Apheresis"
DOI: 10.1002/jca.21768
Abstract: Case patient A is a 9-years-old Caucasian girl who presented with altered mental status. Three weeks prior to presentation, the patient's mother reported a gradual onset of dizziness, intermittent vomiting, and behavioral changes. She developed… read more here.
Keywords: plasma exchange; patient; anti; nmda receptor ... See more keywords
Pharmacological characterization and differential expression of NMDA receptor subunits in the chicken vestibular system during development
Sign Up to like & getrecommendations! Published in 2022 at "Synapse"
DOI: 10.1002/syn.22252
Abstract: Previous studies demonstrated that in vitro preparations of the isolated vestibular system of diverse animal species still exhibit stable resting electrical activity and mechanically evoked synaptic transmission between hair cells and primary afferent endings. However,… read more here.
Keywords: system; nmda receptor; mechanically evoked; chicken vestibular ... See more keywords
NMDA Receptor Antagonists
Sign Up to like & getrecommendations! Published in 2019 at "Pain"
DOI: 10.1007/978-3-319-99124-5_62
Abstract: NMDA receptor antagonists have a number of indications in chronic and acute pain. While ketamine represents the most frequently utilized analgesic from this group, other agents possess similar properties. The use of ketamine has been… read more here.
Keywords: receptor antagonists; nmda receptor;
The witchcraft of encephalitis in Salem
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neurology"
DOI: 10.1007/s00415-017-8546-4
Abstract: Dear Sirs, The study of the causes of bewitchment throughout history has captured the imagination of both modern historians and scientists. In an article in Science in 1976, Caporael proposed convulsive ergotism, from the rye… read more here.
Keywords: receptor encephalitis; nmda receptor; salem; anti nmda ... See more keywords
Cerebrospinal fluid MOG-antibodies in anti-NMDA receptor encephalitis with leptomeningeal enhancement
Sign Up to like & getrecommendations! Published in 2020 at "Neurological Sciences"
DOI: 10.1007/s10072-020-04343-3
Abstract: IgG antibodies against myelin oligodendrocyte glycoprotein (MOG) are associated with acute demyelinating encephalomyelitis [1], neuromyelitis optica, cortical encephalitis [2, 3], or aseptic meningitis [4]. MOG-antibodies are usually examined in serum but rarely detected exclusively in… read more here.
Keywords: nmda receptor; anti nmda; encephalitis; mog ... See more keywords
Alteration in NMDA Receptor Mediated Glutamatergic Neurotransmission in the Hippocampus During Senescence
Sign Up to like & getrecommendations! Published in 2018 at "Neurochemical Research"
DOI: 10.1007/s11064-018-2634-4
Abstract: Glutamate is the primary excitatory neurotransmitter in neurons and glia. N-methyl-d-aspartate (NMDA), α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), and kainate receptors are major ionotropic glutamate receptors. Glutamatergic neurotransmission is strongly linked with Ca2+ homeostasis. Research has provided ample… read more here.
Keywords: nmda receptor; senescence; neurotransmission; mediated glutamatergic ... See more keywords
Implication of Genes for the N-Methyl-d-Aspartate (NMDA) Receptor in Substance Addictions
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Neurobiology"
DOI: 10.1007/s12035-018-0877-3
Abstract: Drug dependence is a chronic brain disease with harmful consequences for both individual users and society. Glutamate is a primary excitatory neurotransmitter in the brain, and both in vivo and in vitro experiments have implicated… read more here.
Keywords: methyl aspartate; implication genes; etiology; nmda receptor ... See more keywords
The NMDA Receptor Subunit (GluN1 and GluN2A) Modulation Following Different Conditions of Cocaine Abstinence in Rat Brain Structures
Sign Up to like & getrecommendations! Published in 2021 at "Neurotoxicity Research"
DOI: 10.1007/s12640-021-00350-0
Abstract: Different neuronal alterations within glutamatergic system seem to be crucial for developing of cocaine-seeking behavior. Cocaine exposure provokes a modulation of the NMDA receptor subunit expression in rodents, which probably contributes to cocaine-induced behavioral alterations.… read more here.
Keywords: cocaine; subunit; cocaine abstinence; nmda receptor ... See more keywords
Autoimmune Encephalitis: NMDA Receptor Encephalitis as an Example of Translational Neuroscience
Sign Up to like & getrecommendations! Published in 2020 at "Neurotherapeutics"
DOI: 10.1007/s13311-020-00861-2
Abstract: Autoimmune encephalitis (AE) is a group of disorders causing synaptic receptor dysfunction with a broad range of neurological symptoms that has been historically difficult to differentiate clinically. Today, AE represents an excellent example of the… read more here.
Keywords: autoimmune encephalitis; basic science; nmda receptor; example ... See more keywords
Pharmacological evidence for the relationship between the NMDA receptor and nitric oxide pathway and the antidepressant-like effects of glucagon-like peptide-2 in the mouse forced-swim test
Sign Up to like & getrecommendations! Published in 2019 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2019.02.028
Abstract: Highlightsd‐serine and l‐arginine inhibited the antidepressant‐like effects of GLP‐2 in the mouse FST.PDE5 inhibitor inhibited the antidepressant‐like effects of GLP‐2.GLP‐2 and NMDA receptor‐NO‐cGMP pathway exerted synergistic effects in the FST. &NA; We previously demonstrated that… read more here.
Keywords: effects glp; nmda receptor; like effects; nitric oxide ... See more keywords