Negative allosteric modulators of NMDA receptors with GluN2B subunit: Alanine‐derived benzoxazolone bioisosteres of 2‐methyl‐3‐benzazepine‐1,7‐diols
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200177
Abstract: Inspired by besonprodil, the phenol of potent negative allosteric modulators of GluN2B‐N‐methyl‐d‐aspartate (NMDA) receptors was replaced by a benzoxazolone system. To increase the similarity to the lead compounds, an additional methyl moiety was installed in… read more here.
Keywords: nmda receptors; allosteric modulators; moiety; benzoxazolone ... See more keywords
Microglia actively remove NR1 autoantibody-bound NMDA receptors and associated post-synaptic proteins in neuron microglia co-cultures.
Sign Up to like & getrecommendations! Published in 2023 at "Glia"
DOI: 10.1002/glia.24369
Abstract: Autoantibodies against the NR1 subunit of NMDA receptors (NMDARs) have been shown to promote crosslinking and internalization of bound receptors in NMDAR encephalitis (NMDARE). This internalization-mediated loss of NMDARs is thought to be the major… read more here.
Keywords: nr1 autoantibody; nmda receptors; autoantibody; synaptic proteins ... See more keywords
The environmental pollutant BDE-209 regulates NO/cGMP signaling through activation of NMDA receptors in neurons
Sign Up to like & getrecommendations! Published in 2017 at "Environmental Science and Pollution Research"
DOI: 10.1007/s11356-017-0651-5
Abstract: The common flame retardant decabrominated diphenyl ether (BDE-209) is a persistent organic pollutant. Epidemiological studies have revealed that prenatal or postnatal exposure to BDE-209 can result in delayed cognitive development, and BDE-209 has been shown… read more here.
Keywords: bde; activation nmda; cgmp signaling; bde 209 ... See more keywords
Regulation of NMDA receptors and plasticity in the BNST following adolescent alcohol exposure
Sign Up to like & getrecommendations! Published in 2017 at "Alcohol"
DOI: 10.1016/j.alcohol.2017.02.272
Abstract: Persistent alterations in synaptic plasticity and neurotransmission are thought to underlie the heightened risk of adolescent-onset drinkers to develop alcohol use disorders in adulthood. The bed nucleus of the stria terminalis (BNST) is a compelling… read more here.
Keywords: nmda receptors; alcohol; exposure; adolescent alcohol ... See more keywords
Attenuation of noise-induced hyperactivity in the dorsal cochlear nucleus by pre-treatment with MK-801
Sign Up to like & getrecommendations! Published in 2018 at "Brain Research"
DOI: 10.1016/j.brainres.2018.01.002
Abstract: It has previously been hypothesized that hyperactivity of central auditory neurons following exposure to intense noise is a consequence of synaptic alterations. Recent studies suggest the involvement of NMDA receptors in the induction of this… read more here.
Keywords: hyperactivity; exposure; intense sound; noise ... See more keywords
NMDA receptors elicit flux-independent intracellular Ca2+ signals via metabotropic glutamate receptors and flux-dependent nitric oxide release in human brain microvascular endothelial cells.
Sign Up to like & getrecommendations! Published in 2021 at "Cell calcium"
DOI: 10.1016/j.ceca.2021.102454
Abstract: The excitatory neurotransmitter glutamate gates post-synaptic N-methyl-d-aspartate (NMDA) receptors (NMDARs) to mediate extracellular Ca2+ entry and stimulate neuronal nitric oxide (NO) synthase to release NO and trigger neurovascular coupling (NVC). Neuronal and glial NMDARs may… read more here.
Keywords: brain microvascular; flux independent; ca2; nmda receptors ... See more keywords
Supramolecular organization of NMDA receptors and the postsynaptic density
Sign Up to like & getrecommendations! Published in 2017 at "Current opinion in neurobiology"
DOI: 10.1016/j.conb.2017.05.019
Abstract: The postsynaptic density (PSD) of all vertebrate species share a highly complex proteome with ~1000 conserved proteins that function as sophisticated molecular computational devices. Here, we review recent studies showing that this complexity can be… read more here.
Keywords: organization nmda; nmda receptors; supramolecular organization; postsynaptic density ... See more keywords
Melatonin reverts methamphetamine-induced learning and memory impairments and hippocampal alterations in mice.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.118844
Abstract: AIMS Methamphetamine (METH) has become a major public health problem because of its abuse and profound neurotoxic effects, causing alterations in brain structure and function, and impairing cognitive functions, including attention, decision making, emotional memory,… read more here.
Keywords: bdnf nmda; learning memory; meth induced; mel ... See more keywords
A lack of GluN2A-containing NMDA receptors confers a vulnerability to redox dysregulation: Consequences on parvalbumin interneurons, and their perineuronal nets
Sign Up to like & getrecommendations! Published in 2018 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2017.10.006
Abstract: The GluN2A subunit of NMDA receptors (NMDARs) plays a critical role during postnatal brain development as its expression increases while Glun2B expression decreases. Mutations and polymorphisms in GRIN2A gene, coding for GluN2A, are linked to… read more here.
Keywords: parvalbumin interneurons; glun2a containing; lack glun2a; glun2a ... See more keywords
Prenatal exposure to lambda‐cyhalothrin impairs memory in developing rats: Role of NMDA receptor induced post‐synaptic signalling in hippocampus
Sign Up to like & getrecommendations! Published in 2017 at "Neurotoxicology"
DOI: 10.1016/j.neuro.2017.04.011
Abstract: HIGHLIGHTSPrenatal exposure to LCT altered expression of NMDA receptors in developing rats.Alteration in postsynaptic signaling in hippocampus of developing rats also evident.Changes associated with impairment in memory of rats on PD22 and PD45.Changes found to… read more here.
Keywords: exposure; developing rats; lct; prenatal exposure ... See more keywords
Revealing a Role for NMDA Receptors in Regulating STN Inputs following the Loss of Dopamine
Sign Up to like & getrecommendations! Published in 2017 at "Neuron"
DOI: 10.1016/j.neuron.2017.08.041
Abstract: In this issue of Neuron, Chu et al. (2017) show that dopamine depletion using a 6-OHDA model causes a decrease in hyperdirect inputs from the motor cortex directly to the STN and that rescuing this loss… read more here.
Keywords: receptors regulating; role nmda; revealing role; nmda receptors ... See more keywords