What is the evidence to support the use of plasma exchange as first‐line therapy for N‐methyl d‐aspartate receptor antibody encephalitis?
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Apheresis"
DOI: 10.1002/jca.21567
Abstract: The recently published seventh edition of the “Guidelines on the Use of Therapeutic Apheresis in Clinical Practice” outlines the available evidence supporting and refuting the use of therapeutic apheresis as a medical treatment. The authors… read more here.
Keywords: use; line; nmdar; treatment ... See more keywords
Gene Targeted Mice with Conditional Knock-In (-Out) of NMDAR Mutations.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7321-7_11
Abstract: For the genetic alterations of NMDA receptor (NMDAR) properties like Ca2+-permeability or voltage-dependent gating in mice and for the experimental analysis of nonsense or missense mutations that were identified in human patients, single nucleotide mutations… read more here.
Keywords: gene targeted; nmdar; nmdar mutations; targeting vector ... See more keywords
Autoimmune Enzephalitiden – diagnostischer und therapeutischer Entscheidungsbaum aus psychiatrischer, neurologischer und ethisch-juristischer Sicht
Sign Up to like & getrecommendations! Published in 2019 at "Der Nervenarzt"
DOI: 10.1007/s00115-019-00802-1
Abstract: Bei einem nicht einwilligungsfähigen Patienten mit schwerer psychischer Störung besteht zwar häufig die Notwendigkeit einer raschen Diagnostik und Therapie, das Symptombild führt jedoch nicht selten zu einer Ablehnung solcher Maßnahmen. In der täglichen Praxis stellt… read more here.
Keywords: autoimmune enzephalitiden; die; nmdar; treatment ... See more keywords
Regional-specific effects of cerebral ischemia/reperfusion and dehydroepiandrosterone on synaptic NMDAR/PSD-95 complex in male Wistar rats
Sign Up to like & getrecommendations! Published in 2018 at "Brain Research"
DOI: 10.1016/j.brainres.2018.03.023
Abstract: Excessive glutamate efflux and N-methyl-D-aspartate receptor (NMDAR) over-activation represent well-known hallmarks of cerebral ischemia/reperfusion (I/R) injury, still, expression of proteins involved in this aspect of I/R pathophysiology show inconsistent data. Neurosteroid dehydroepiandrosterone (DHEA) has been… read more here.
Keywords: nmdar; cerebral ischemia; male wistar; synaptic nmdar ... See more keywords
NMDA receptors containing GluN2C and GluN2D subunits have opposing roles in modulating neuronal oscillations; potential mechanism for bidirectional feedback
Sign Up to like & getrecommendations! Published in 2020 at "Brain Research"
DOI: 10.1016/j.brainres.2019.146571
Abstract: NMDA receptor (NMDAR) antagonists such as ketamine, can reproduce many of the symptoms of schizophrenia. A reliable indicator of NMDAR channel blocker action in vivo is the augmentation of neuronal oscillation power. Since the coordinated… read more here.
Keywords: oscillatory power; nmdar; power; glun2c glun2d ... See more keywords
GKAP Acts as a Genetic Modulator of NMDAR Signaling to Govern Invasive Tumor Growth
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Cell"
DOI: 10.1016/j.ccell.2018.02.011
Abstract: Summary Genetic linkage analysis previously suggested that GKAP, a scaffold protein of the N-methyl-D-aspartate receptor (NMDAR), was a potential modifier of invasion in a mouse model of pancreatic neuroendocrine tumor (PanNET). Here, we establish that… read more here.
Keywords: acts genetic; nmdar; gkap acts; growth ... See more keywords
Age-related changes in the number of cresyl-violet-stained, parvalbumin and NMDAR 2B expressing neurons in the human spiral ganglion
Sign Up to like & getrecommendations! Published in 2020 at "Hearing Research"
DOI: 10.1016/j.heares.2020.107883
Abstract: Animal-studies associate age-related hearing loss (presbycusis) with decreasing number of spiral ganglion neurons (SGNs) in Rosenthal's canal (RC) of cochlea. The excitatory neurotransmitter for SGNs is glutamate (through its receptor NMDAR 2B), which can be… read more here.
Keywords: age related; age; nmdar; number ... See more keywords
AQP4-IgG-seropositive neuromyelitis optica spectrum disorder (NMOSD) coexisting with anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis: A case report and literature review.
Sign Up to like & getrecommendations! Published in 2019 at "Multiple sclerosis and related disorders"
DOI: 10.1016/j.msard.2019.07.008
Abstract: BACKGROUND Neuromyelitis optica spectrum disorder (NMOSD) can coexist with anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis. Patients with overlapping Aquaporin 4 immunoglobulin G (AQP4-IgG)-seropositive NMOSD and anti-NMDAR encephalitis with positive NMDAR antibodies in the cerebrospinal fluid (CSF) are… read more here.
Keywords: igg seropositive; nmdar; case; nmdar encephalitis ... See more keywords
Computational Molecular Characterization of the Interaction of Acetylcholine and the NMDA Receptor to Explain the Direct Glycine-Competitive Potentiation of NMDA-Mediated Neuronal Currents.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.1c00639
Abstract: The activation of N-methyl-d-aspartate receptor (NMDAR) is triggered by the closure of bilobed (D1 and D2) clamshell-like clefts upon binding glycine (Gly) and glutamate. There is evidence that cholinergic compounds modulate NMDAR-mediated currents via direct… read more here.
Keywords: neuronal currents; nmdar; potentiation nmda; glycine ... See more keywords
Ethanol Metabolite, Acetate, Increases Excitability of the Central Nucleus of Amygdala Neurons through Activation of NMDA Receptors.
Sign Up to like & getrecommendations! Published in 2023 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.2c00784
Abstract: The central nucleus of the amygdala (CeA) is a key brain region involved in emotional and stressor responses due to its many projections to autonomic regulatory centers. It is also a primary site of action… read more here.
Keywords: central nucleus; nmdar; acetate; nucleus amygdala ... See more keywords
Cognitive Signaling in Cerebellar Granule Cells
Sign Up to like & getrecommendations! Published in 2018 at "Neuropsychopharmacology"
DOI: 10.1038/npp.2017.186
Abstract: ketamine’s dissociative side effects and abuse potential has led to the search for identification of alternative compounds that trigger rapid antidepressant effects without the psychotomimetic side effects. A successful effort will require elucidation of the… read more here.
Keywords: nmdar; ketamine; signaling pathway; hnk ... See more keywords