Effects of NMDAR Antagonist on the Regulation of P-MARCKS Protein to Aβ1−42 Oligomers Induced Neurotoxicity
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DOI: 10.1007/s11064-018-2622-8
Abstract: Alzheimer’s disease (AD) is a well-known neurodegenerative disease. Deposition of β-amyloid protein (Aβ) oligomers plays a crucial role in the disease progression. Previous studies showed that toxicity induced by Aβ oligomers in cultured neurons and… read more here.
Keywords: regulation marcks; oligomers induced; nmdar antagonist; neurotoxicity ... See more keywords
Dose-dependent suppression of hippocampal contextual memory formation, place cells, and spatial engrams by the NMDAR antagonist (R)-CPP
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DOI: 10.1101/2022.06.13.495957
Abstract: A common way to study the functional importance of N-methyl-D-aspartate receptors (NMDARs) in hippocampal memory-encoding circuits is by administering NMDAR antagonists. We recently compared the effects of (R,S)-3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP), a competitive NMDAR antagonist, on… read more here.
Keywords: place cells; cells spatial; cpp; suppression ... See more keywords