NMDA receptor-dependent long-term depression in the lateral habenula: implications in physiology and depression
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-74496-w
Abstract: Abnormally increased neuronal activity in the lateral habenula (LHb) is closely associated with depressive-like behavior. Despite the emphasis on the pathological importance of NMDA receptor (NMDAR)-dependent long-term depression (LTD) and the involvement of calcium permeable… read more here.
Keywords: depression; physiology; receptor; nmdar dependent ... See more keywords
Social memory engram formation impairment in neuroligin-3 R451C knock-in mice is caused by disrupted prefrontal NMDA receptor-dependent potentiation
Sign Up to like & getrecommendations! Published in 2025 at "Communications Biology"
DOI: 10.1038/s42003-025-08806-1
Abstract: Autism spectrum disorders (ASDs) are characterized by profound social cognitive deficits, including impairments in social memory—the ability to recognize and remember familiar conspecifics. However, the mechanisms underlying these deficits remain poorly understood. Here, we identify… read more here.
Keywords: memory; neuroligin r451c; nmdar dependent; social memory ... See more keywords