GABABR activation partially normalizes acute NMDAR hypofunction oscillatory abnormalities but fails to rescue sensory processing deficits
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.15602
Abstract: Cognitive deficits and impaired sensory processing are hallmarks of several neurodevelopmental and neuropsychiatric disorders. N‐methyl‐d‐aspartate receptor (NMDAR) hypofunction contributes to these deficits by disrupting the excitation‐to‐inhibition balance in neuronal networks. Although preclinical data suggest that… read more here.
Keywords: sensory processing; fails rescue; hypofunction; partially normalizes ... See more keywords
Neural substrates of cognitive impairment in a NMDAR hypofunction mouse model of schizophrenia and partial rescue by risperidone
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2023.1152248
Abstract: N-methyl D-aspartate receptor (NMDAR) hypofunction is a pathophysiological mechanism relevant for schizophrenia. Acute administration of the NMDAR antagonist phencyclidine (PCP) induces psychosis in patients and animals while subchronic PCP (sPCP) produces cognitive dysfunction for weeks.… read more here.
Keywords: term; risperidone; schizophrenia; memory ... See more keywords