NYX-2925 induces metabotropic NMDAR signaling that enhances synaptic NMDAR and AMPAR.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of neurochemistry"
DOI: 10.1111/jnc.14845
Abstract: N-Methyl-D-Aspartate receptors (NMDARs) mediate both physiological and pathophysiological processes, though selective ligands lack broad clinical utility. NMDARs are composed of multiple subunits, but GluN2 is predominately responsible for functional heterogeneity. Specifically, the GluN2A- and GluN2B-containing… read more here.
Keywords: nmdar signaling; glun2b; synaptic glun2b; nyx 2925 ... See more keywords
Flux-Independent NMDAR Signaling: Molecular Mediators, Cellular Functions, and Complexities
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DOI: 10.3390/ijms19123800
Abstract: The glutamate (Glu) N-methyl-d-aspartate (NMDA) receptor (NMDAR) plays a critical role in synaptic communication given mainly by its ionotropic function that permeates Ca2+. This in turn activates calmodulin that triggers CaMKII, MAPK, CREB, and PI3K… read more here.
Keywords: signaling molecular; independent nmdar; nmdar; flux independent ... See more keywords
NMDA Receptor and Its Emerging Role in Cancer
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DOI: 10.3390/ijms24032540
Abstract: Glutamate is a key player in excitatory neurotransmission in the central nervous system (CNS). The N-methyl-D-aspartate receptor (NMDAR) is a glutamate-gated ion channel which presents several unique features and is involved in various physiological and… read more here.
Keywords: glutamate; role; nmdar signaling; receptor ... See more keywords