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   Articles with "nmmhc iia" as a keyword



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Myosin IIA Regulated Tight Junction in Oxygen Glucose-Deprived Brain Endothelial Cells Via Activation of TLR4/PI3K/Akt/JNK1/2/14-3-3ε/NF-κB/MMP9 Signal Transduction Pathway

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recommendations! Published in 2019 at "Cellular and Molecular Neurobiology"

DOI: 10.1007/s10571-019-00654-y

Abstract: Non-muscle myosin heavy chain IIA (NMMHC IIA), a member of Myosin II family, plays a critical role in various cellular physiological processes. Our previous research had suggested that NMMHC IIA could participate in regulating tight… read more here.

Keywords: transduction pathway; nmmhc iia; endothelial cells; junction ... See more keywords
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MYH9 gene mutations associated with bleeding

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recommendations! Published in 2017 at "Platelets"

DOI: 10.1080/09537104.2017.1294250

Abstract: MYH9 is a large gene localized on chromosome 22q12.3-13.1 constituted of one 5ˊ-untranslated (exon 1) and 40 coding exons (Figure 1). It encodes for the heavy chain of the nonmuscle myosin IIA (NMMHC-IIA), a cytoplasmic… read more here.

Keywords: thrombocytopenia; myh9; nmmhc iia; nonhelical tail ... See more keywords
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Endothelial Conditional Knockdown of NMMHC IIA (Nonmuscle Myosin Heavy Chain IIA) Attenuates Blood-Brain Barrier Damage During Ischemia-Reperfusion Injury

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recommendations! Published in 2021 at "Stroke"

DOI: 10.1161/strokeaha.120.031410

Abstract: Supplemental Digital Content is available in the text. Background and Purpose: In ischemic stroke, breakdown of the blood-brain barrier (BBB) aggravates brain damage. Endothelial detachment contributes to BBB disruption and neurovascular dysfunction, but its regulation… read more here.

Keywords: damage; ischemia reperfusion; nmmhc iia; barrier ... See more keywords
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NMMHC IIA Inhibition Ameliorates Cerebral Ischemic/Reperfusion-Induced Neuronal Apoptosis Through Caspase-3/ROCK1/MLC Pathway

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recommendations! Published in 2020 at "Drug Design, Development and Therapy"

DOI: 10.2147/dddt.s230882

Abstract: Purpose Our previous studies have indicated that non-muscle myosin heavy chain IIA (NMMHC IIA) is involved in H2O2-induced neuronal apoptosis, which is associated with the positive feedback loop of caspase-3/ROCK1/MLC pathway. However, the neuroprotective effect… read more here.

Keywords: iia; rock1 mlc; neuronal apoptosis; nmmhc iia ... See more keywords
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Renal injury associated with MYH9 disorder with 5773delG mutation: A case report.

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recommendations! Published in 2023 at "Clinical nephrology"

DOI: 10.5414/cn110772

Abstract: A 35-year-old man with persistent urine abnormalities and renal dysfunction was referred to our hospital. May-Hegglin anomaly was suspected, and a renal biopsy showed focal segmental glomerulosclerosis (FSGS) with IgA deposition. Electron microscopy revealed foot… read more here.

Keywords: nmmhc iia; associated myh9; 5773delg mutation; myh9 disorder ... See more keywords