NAD-biosynthetic enzyme NMNAT1 reduces early behavioral impairment in the htau mouse model of tauopathy
Sign Up to like & getrecommendations! Published in 2018 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2017.11.030
Abstract: HIGHLIGHTSFirst investigation of the role of NMNAT1 in the early stage of tauopathies in mice.htau mice display a robust deficit in food burrowing prior to onset of cognitive symptoms.NMNAT1 overexpression rescues this behavioral abnormality. ABSTRACT… read more here.
Keywords: nad biosynthetic; htau mice; model tauopathy; nmnat1 ... See more keywords
Targeting Nuclear NAD+ Synthesis Inhibits DNA Repair, Impairs Metabolic Adaptation and Increases Chemosensitivity of U-2OS Osteosarcoma Cells
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DOI: 10.3390/cancers12051180
Abstract: Osteosarcoma (OS) is the most common bone tumor in children and adolescents. Modern OS treatment, based on the combination of neoadjuvant chemotherapy (cisplatin + doxorubicin + methotrexate) with subsequent surgical removal of the primary tumor… read more here.
Keywords: nad synthesis; osteosarcoma; osteosarcoma cells; 2os osteosarcoma ... See more keywords