Structural and biophysical insight into dual site binding of the protoberberine alkaloid palmatine to parallel G-quadruplex DNA using NMR, fluorescence and Circular Dichroism spectroscopy.
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DOI: 10.1016/j.biochi.2018.02.002
Abstract: Plant derived small molecules, which interact with and stabilize G-quadruplex DNA, act as inhibitors of telomere elongation and oncogene expression in humans. The inhibition of telomerase enzyme has immense potential since it is over expressed… read more here.
Keywords: dna; quadruplex dna; nmr fluorescence; spectroscopy ... See more keywords