Using NMR to Monitor TET-Dependent Methylcytosine Dioxygenase Activity and Regulation.
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DOI: 10.1021/acschembio.3c00619
Abstract: The active removal of DNA methylation marks is governed by the ten-eleven translocation (TET) family of enzymes (TET1-3), which iteratively oxidize 5-methycytosine (5mC) into 5-hydroxymethycytosine (5hmC), and then 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC). TET proteins… read more here.
Keywords: nmr monitor; using nmr; activity; regulation ... See more keywords