In vivo Structure‐Activity Relationship of Dihydromethysticin in Reducing Nicotine‐Derived Nitrosamine Ketone (NNK)‐Induced Lung DNA Damage against Lung Carcinogenesis in A/J Mice
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DOI: 10.1002/cmdc.202100727
Abstract: Lung cancer is the leading cause of cancer‐related deaths and chemoprevention should be developed. We recently identified dihydromethysticin (DHM) as a promising candidate to prevent NNK‐induced lung tumorigenesis. To probe its mechanisms and facilitate its… read more here.
Keywords: lung; dna damage; induced lung; nnk induced ... See more keywords
Suppressing the activation of protein kinase A as a DNA damage-independent mechanistic lead for dihydromethysticin (DHM) prophylaxis of NNK-induced lung carcinogenesis.
Sign Up to like & getrecommendations! Published in 2022 at "Carcinogenesis"
DOI: 10.1093/carcin/bgac031
Abstract: Our earlier work demonstrated varying potency of dihydromethysticin (DHM) as the active kava phytochemical for prophylaxis of tobacco carcinogen NNK-induced mouse lung carcinogenesis. Efficacy was dependent on timing of DHM gavage ahead of NNK insult.… read more here.
Keywords: damage; lung carcinogenesis; nnk induced; damage independent ... See more keywords