A surface magnetic imprinted polymers as artificial receptors for selective and efficient capturing of new neuronal nitric oxide synthase–post synaptic density protein‐95 uncouplers
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2018.03.003
Abstract: HIGHLIGHTSA surface magnetic molecularly imprinted polymers (SMMIPs) procedure was developed.Good selection of SMMIPs was achieved using optimization experimental conditions.SMMIPs were applied for specific isolation of potential nNOS–PSD‐95 uncouplers from complex samples.The isolated potential nNOS–PSD‐95 uncouplers… read more here.
Keywords: artificial receptors; neuronal nitric; nnos psd; psd uncouplers ... See more keywords
Development of a Potent Cyclic Peptide Inhibitor of the nNOS/PSD-95 Interaction.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01803
Abstract: The complex between the N-methyl-d-aspartate receptor (NMDAR), neuronal nitric oxide synthase (nNOS), and the postsynaptic density protein-95 (PSD-95) is an attractive therapeutic target for the treatment of acute ischemic stroke. The complex is formed via… read more here.
Keywords: interaction; inhibitor nnos; peptide; psd interaction ... See more keywords
A pain killer without analgesic tolerance designed by co-targeting PSD-95-nNOS interaction and α2-containning GABAARs
Sign Up to like & getrecommendations! Published in 2021 at "Theranostics"
DOI: 10.7150/thno.58364
Abstract: Overactivation of N-methyl-D-aspartate receptor (NMDAR) in the spinal cord dorsal horn (SDH) in the setting of injury represents a key mechanism of neuropathic pain. However, directly blocking NMDAR or its downstream signaling, interaction between postsynaptic… read more here.
Keywords: tolerance; nnos psd; interaction; analgesic tolerance ... See more keywords