Discovery, synthesis, and optimization of an N-alkoxy indolylacetamide against HIV-1 carrying NNRTI-resistant mutations from the Isatis indigotica root
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DOI: 10.1016/j.ejmech.2020.112071
Abstract: Abstract From an aqueous decoction of the traditional Chinese medicine “ban lan gen” (the Isatis indigotica root), an antiviral natural product CI - 39 was isolated as an NNRTI (non-nucleoside reverse transcriptase inhibitor) (EC50 = 3.40 μM). Its novel structure… read more here.
Keywords: discovery synthesis; isatis indigotica; indigotica root; nnrti resistant ... See more keywords