Nociceptin/Orphanin FQ (N/OFQ) conjugated to ATTO594: a novel fluorescent probe for the N/OFQ (NOP) receptor
Sign Up to like & getrecommendations! Published in 2018 at "British Journal of Pharmacology"
DOI: 10.1111/bph.14504
Abstract: The nociceptin/orphanin FQ (N/OFQ) receptor (NOP) is a member of the opioid receptor family and is involved in a number of physiological responses, pain and immune regulation as examples. In this study, we conjugated a… read more here.
Keywords: receptor; nociceptin orphanin; nop receptor; orphanin ofq ... See more keywords
Nociceptin/Orphanin FQ peptide receptor (NOP) mediates inhibition of N-type calcium currents in vestibular afferent neurons of the rat.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of neurophysiology"
DOI: 10.1152/jn.00269.2020
Abstract: The vestibular system is modulated by various neuromodulators including opioid peptides. The current study was conducted to determine whether activation of nociceptin/orphanin FQ peptide (NOP) receptors modulates voltage-gated calcium currents and action potential discharge of… read more here.
Keywords: nociceptin orphanin; type calcium; afferent neurons; calcium ... See more keywords
In vitro sepsis induces Nociceptin/Orphanin FQ receptor (NOP) expression in primary human vascular endothelial but not smooth muscle cells
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0274080
Abstract: Sepsis is a dysregulated host response to infection that can cause widespread effects on other organs including cardiovascular depression, hypotension and organ failure. The receptor for Nociceptin/Orphanin FQ (N/OFQ), NOP is expressed on immune cells… read more here.
Keywords: sepsis; vitro sepsis; lps pepg; nociceptin orphanin ... See more keywords
Nociceptin /Orphanin FQ Peptide (NOP) Receptor Modulators: An Update in Structure-Activity Relationships.
Sign Up to like & getrecommendations! Published in 2018 at "Current medicinal chemistry"
DOI: 10.2174/0929867325666180111095458
Abstract: Nociceptin /Orphanin FQ Peptide" receptor (NOPr) is a G-protein-coupled receptor with the nociceptin/orphanin FQ peptide (N/OFQ) as endogenous agonist. It is expressed in the nervous system as well as in some non-neural tissues. Its activation… read more here.
Keywords: receptor; nociceptin orphanin; structure activity; orphanin peptide ... See more keywords
Nociceptin/orphanin FQ peptide receptor-related ligands as novel analgesics.
Sign Up to like & getrecommendations! Published in 2020 at "Current topics in medicinal chemistry"
DOI: 10.2174/1568026620666200508082615
Abstract: Despite similar distribution patterns and intracellular events observed in the nociceptin/orphanin FQ peptide (NOP) receptor and other opioid receptors, NOP receptor activation displays unique pharmacological profiles. Several researchers have identified a variety of peptide and… read more here.
Keywords: receptor activation; peptide; nociceptin orphanin; nop receptor ... See more keywords
Role of Nociceptin/Orphanin FQ-NOP Receptor System in the Regulation of Stress-Related Disorders
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms222312956
Abstract: Nociceptin/orphanin FQ (N/OFQ) is a 17-residue neuropeptide that binds the nociceptin opioid-like receptor (NOP). N/OFQ exhibits nucleotidic and aminoacidics sequence homology with the precursors of other opioid neuropeptides but it does not activate either MOP,… read more here.
Keywords: system; stress; nop receptor; role ... See more keywords
Spotlight on Nociceptin/Orphanin FQ Receptor in the Treatment of Pain
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DOI: 10.3390/molecules27030595
Abstract: In our society today, pain has become a main source of strain on most individuals. It is crucial to develop novel treatments against pain while focusing on decreasing their adverse effects. Throughout the extent of… read more here.
Keywords: nop receptor; pain; orphanin receptor; spotlight nociceptin ... See more keywords
Formulation of Solid Lipid Nanoparticles Loaded with Nociceptin/Orphanin FQ (N/OFQ) and Characterization in a Murine Model of Airway Hyperresponsiveness
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph15101210
Abstract: Asthma is characterized by chronic inflammation and a variable degree of airway hyperresponsiveness (AHR). Our previous papers documented a role for Nociceptin/Orphanin FQ (N/OFQ) and its receptor N/OFQ peptide (NOP) in AHR. Therefore, the aim… read more here.
Keywords: airway hyperresponsiveness; solid lipid; nociceptin orphanin; ofq ... See more keywords