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   Articles with "nociception" as a keyword



Cdyl Deficiency Brakes Neuronal Excitability and Nociception through Promoting Kcnb1 Transcription in Peripheral Sensory Neurons

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recommendations! Published in 2022 at "Advanced Science"

DOI: 10.1002/advs.202104317

Abstract: Epigenetic modifications are involved in the onset, development, and maintenance of pain; however, the precise epigenetic mechanism underlying pain regulation remains elusive. Here it is reported that the epigenetic factor chromodomain Y‐like (CDYL) is crucial… read more here.

Keywords: neuronal excitability; excitability nociception; nociception; pain ... See more keywords

Photothermal Controlled-Release Immunomodulatory Nanoplatform for Restoring Nerve Structure and Mechanical Nociception in Infectious Diabetic Ulcers.

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recommendations! Published in 2023 at "Advanced science"

DOI: 10.1002/advs.202300339

Abstract: Infectious diabetic ulcers (IDU) require anti-infection, angiogenesis, and nerve regeneration therapy; however, the latter has received comparatively less research attention than the former two. In particular, there have been few reports on the recovery of… read more here.

Keywords: infectious diabetic; mechanical nociception; nociception; photothermal controlled ... See more keywords

Phenotypic Screening of Prospective Analgesics Among FDA‐Approved Compounds using an iPSC‐Based Model of Acute and Chronic Inflammatory Nociception

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recommendations! Published in 2024 at "Advanced Science"

DOI: 10.1002/advs.202303724

Abstract: Classical target‐based drug screening is low‐throughput, largely subjective, and costly. Phenotypic screening based on in vitro models is increasingly being used to identify candidate compounds that modulate complex cell/tissue functions. Chronic inflammatory nociception, and subsequent… read more here.

Keywords: phenotypic screening; nociception; model; fda approved ... See more keywords

Effects of experimentally induced lumbar nociception on trunk motor control in the rat during locomotion

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recommendations! Published in 2025 at "Experimental Brain Research"

DOI: 10.1007/s00221-025-07041-8

Abstract: Nociception resulting in pain perception might be one of the factors contributing to the motor control changes in people with low-back pain. However, limited evidence exists regarding the effects of acute pain on trunk motor… read more here.

Keywords: hypertonic saline; nociception; locomotion; motor control ... See more keywords

Antinociceptive effects of the adenylyl cyclase inhibitor ST034307 on tooth-movement-induced nociception in rats.

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recommendations! Published in 2019 at "Archives of oral biology"

DOI: 10.1016/j.archoralbio.2018.11.012

Abstract: OBJECTIVE This study aimed to investigate the antinociceptive effects of the selective adenylyl cyclase type 1 (AC1) inhibitor ST034307 on tooth movement nociception through orofacial nociceptive behavior tests and molecular examination. METHODS We placed fixed… read more here.

Keywords: movement; nociception; adenylyl cyclase; tooth movement ... See more keywords
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[Guiding opioid-free intravenous antinociception with the Analgesia Nociception Index: a case report].

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recommendations! Published in 2020 at "Revista brasileira de anestesiologia"

DOI: 10.1016/j.bjan.2020.07.005

Abstract: BACKGROUND Opioid-free anesthesia decreases the incidence of opioid adverse events, but its optimal antinociceptive depth has not been clearly defined. Personalizing intraoperative opioid-free infusions with a nociception monitor may be the solution. CASE REPORT We… read more here.

Keywords: nociception; analgesia nociception; antinociception; opioid free ... See more keywords
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Guiding opioid-free intravenous antinociception with the Analgesia Nociception Index: a case report

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recommendations! Published in 2020 at "Revista Brasileira De Anestesiologia"

DOI: 10.1016/j.bjane.2020.07.010

Abstract: Abstract Background Opioid-free anesthesia decreases the incidence of opioid adverse events, but its optimal antinociceptive depth has not been clearly defined. Personalizing intraoperative opioid-free infusions with a nociception monitor may be the solution. Case report… read more here.

Keywords: nociception; analgesia nociception; antinociception; opioid free ... See more keywords

Machine learning based method for the evaluation of the Analgesia Nociception Index in the assessment of general anesthesia

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recommendations! Published in 2020 at "Computers in biology and medicine"

DOI: 10.1016/j.compbiomed.2020.103645

Abstract: Measuring the level of analgesia to adapt the opioids infusion during anesthesia to the real needs of the patient is still a challenge. This is a consequence of the absence of a specific measure capable… read more here.

Keywords: index; machine learning; nociception; analgesia nociception ... See more keywords
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Is the orofacial antinociceptive effect of lectins intrinsically related to their specificity to monosaccharides?

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recommendations! Published in 2020 at "International journal of biological macromolecules"

DOI: 10.1016/j.ijbiomac.2020.06.132

Abstract: Lectins are proteins of non-immunological origin that may play several biological applications, of which we can highlight the anti-inflammatory and antinociceptive activities. In this work, we evaluated the possible effect of orofacial antinociceptive activity of… read more here.

Keywords: antinociceptive effect; lectins intrinsically; nociception; effect lectins ... See more keywords

The ATP Transporter VNUT Mediates Induction of Dectin-1-Triggered Candida Nociception

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recommendations! Published in 2018 at "iScience"

DOI: 10.1016/j.isci.2018.08.007

Abstract: Summary Candida albicans infection can cause skin, vulvar, or oral pain. Despite the obvious algesic activity of C. albicans, the molecular mechanisms of fungal nociception remain largely unknown. Here we show that the C. albicans-specific… read more here.

Keywords: transporter vnut; nociception; atp transporter; vnut ... See more keywords

Echinodorus macrophyllus fraction with a high level of flavonoid inhibits peripheral and central mechanisms of nociception

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recommendations! Published in 2021 at "Journal of Traditional and Complementary Medicine"

DOI: 10.1016/j.jtcme.2021.07.001

Abstract: Abstract Background and aim: Echinodorus macrophyllus (Kunth.) Micheli is popularly used for acute and chronic inflammatory conditions. The anti-inflammatory activity was previously demonstrated for its flavonoid-enriched fractions. The aim of this work assessed the antinociceptive… read more here.

Keywords: fr40; echinodorus; central mechanisms; nociception ... See more keywords