Crosstalk from cAMP to ERK1/2 emerges during postnatal maturation of nociceptive neurons and is maintained during aging
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cell Science"
DOI: 10.1242/jcs.197327
Abstract: ABSTRACT Maturation of nociceptive neurons depends on changes in transcription factors, ion channels and neuropeptides. Mature nociceptors initiate pain in part by drastically reducing the activation threshold via intracellular sensitization signaling. Whether sensitization signaling also… read more here.
Keywords: also known; nociceptive neurons; maturation nociceptive; crosstalk camp ... See more keywords
TNF-α Increases Production of Reactive Oxygen Species through Cdk5 Activation in Nociceptive Neurons
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2018.00065
Abstract: The participation of reactive oxygen species (ROS) generated by NOX1 and NOX2/NADPH oxidase has been documented during inflammatory pain. However, the molecular mechanism involved in their activation is not fully understood. We reported earlier a… read more here.
Keywords: production; nociceptive neurons; cdk5 activation; nox1 nox2 ... See more keywords
Targeting Nociceptive Neurons and Transient Receptor Potential Channels for the Treatment of Migraine
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24097897
Abstract: Migraine is a neurovascular disorder that affects approximately 12% of the global population. While its exact causes are still being studied, researchers believe that nociceptive neurons in the trigeminal ganglia play a key role in… read more here.
Keywords: nociceptive neurons; targeting nociceptive; transient receptor; migraine ... See more keywords