Metformin antinociceptive effect in models of nociceptive and neuropathic pain is partially mediated by activation of opioidergic mechanisms.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2019.172497
Abstract: Metformin, an AMP-activated protein kinase (AMPK) activator, is an oral hypoglycemic drug widely used to treat patients with type 2 diabetes. As AMPK plays a role in the nociceptive processing, investigating the effects induced by… read more here.
Keywords: activation opioidergic; metformin; nociceptive neuropathic; neuropathic pain ... See more keywords
Tricyclic Antidepressants in Nociceptive and Neuropathic Pain: A Review of Their Analgesic Properties in Combination With Opioids
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Pharmacy Technology"
DOI: 10.1177/87551225221139699
Abstract: Objectives: To determine the efficacy and safety of commonly prescribed tricyclic antidepressants (TCAs) as analgesics for nociceptive and neuropathic pain in combination with opioids. Data Sources: A comprehensive literature review was conducted with the assistance… read more here.
Keywords: tricyclic antidepressants; review; nociceptive neuropathic; neuropathic pain ... See more keywords