Ketamine potentiates TRPV1 receptor signaling in the peripheral nociceptive pathways.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2020.114210
Abstract: TRPV1 is a cation channel expressed in peripheral nociceptive pathways and its activation can trigger nociception signals to the brain. Ketamine is an intravenous anesthetic routinely used for anesthesia induction and with potent analgesic activity.… read more here.
Keywords: nociceptive pathways; ketamine; peripheral nociceptive; trpv1 receptor ... See more keywords
Perceptual correlates of homosynaptic long-term potentiation in human nociceptive pathways: a replication study
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DOI: 10.1098/rsos.200830
Abstract: Animal studies have shown that high-frequency stimulation (HFS) of peripheral C-fibres induces long-term potentiation (LTP) within spinal nociceptive pathways. The aim of this replication study was to assess if a perceptual correlate of LTP can… read more here.
Keywords: term potentiation; replication study; hfs; long term ... See more keywords
Combined Neurophysiologic and Neuroimaging Approach to Reveal the Structure-Function Paradox in Cervical Myelopathy
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DOI: 10.1212/wnl.0000000000012643
Abstract: Background and Objectives To explore the so-called structure-function paradox in individuals with focal spinal lesions by means of tract-specific MRI coupled with multimodal evoked potentials and quantitative sensory testing. Methods Individuals with signs and symptoms… read more here.
Keywords: structure function; function paradox; cervical myelopathy; nociceptive pathways ... See more keywords