NOD‐like receptor protein 3 activation causes spontaneous inflammation and fibrosis that mimics human NASH
Sign Up to like & getrecommendations! Published in 2022 at "Hepatology"
DOI: 10.1002/hep.32320
Abstract: The NOD‐like receptor protein 3 (NLRP3) inflammasome is a central contributor to human acute and chronic liver disease, yet the molecular and cellular mechanisms by which its activation precipitates injury remain incompletely understood. Here, we… read more here.
Keywords: nod like; like receptor; inflammation fibrosis; receptor protein ... See more keywords
The function of NOD‐like receptors in central nervous system diseases
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24004
Abstract: NOD‐like receptors (NLRs) are critical cytoplasmic pattern‐recognition receptors (PRRs) that play an important role in the host innate immune response and immunity homeostasis. There is a growing body of evidence that NLRs are involved in… read more here.
Keywords: nervous system; central nervous; nod like; like receptors ... See more keywords
Calycosin ameliorates doxorubicin‐induced cardiotoxicity by suppressing oxidative stress and inflammation via the sirtuin 1–NOD‐like receptor protein 3 pathway
Sign Up to like & getrecommendations! Published in 2019 at "Phytotherapy Research"
DOI: 10.1002/ptr.6557
Abstract: The limitation of doxorubicin (DOX), which is widely used for the treatment of solid tumors and hematologic malignancies, is a vital problem in clinical application. The most serious of limit factors is cardiotoxicity. Calycosin (CA),… read more here.
Keywords: induced cardiotoxicity; nod like; like receptor; cardiotoxicity ... See more keywords
Structural Biology of NOD-Like Receptors.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-13-9367-9_6
Abstract: The nucleotide-binding domain (NBD) and leucine-rich repeat (LRR) containing (NLR) proteins are a large family of intracellular immune receptors conserved in both animals and plants. Mammalian NLRs function as pattern recognition receptors (PRRs) to sense… read more here.
Keywords: structural biology; biology nod; nod like; biology ... See more keywords
NOD2 and reproduction-associated NOD-like receptors have been lost during the evolution of pangolins
Sign Up to like & getrecommendations! Published in 2021 at "Immunogenetics"
DOI: 10.1007/s00251-021-01230-9
Abstract: NOD-like receptors (NLRs) are sensors of pathogen-associated molecular patterns with critical roles in the control of immune responses and programmed cell death. Recent studies have revealed inter-species differences in mammalian innate immune genes and a… read more here.
Keywords: reproduction associated; nod2 reproduction; nod like; like receptors ... See more keywords
Estrogen receptors participate in carcinogenesis signaling pathways by directly regulating NOD-like receptors.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.02.085
Abstract: Increasing evidence indicates that the NOD-like receptors (NLRs) family may act as critical back-up defenses and provide synergistic responses when confronted with persistent danger. However, the precise regulatory mechanism of NLRs and the contribution of… read more here.
Keywords: directly regulating; estrogen receptors; nod like; receptors participate ... See more keywords
Adipocyte-derived Lysophosphatidylcholine Activates Adipocyte and Adipose Tissue Macrophage Nod-Like Receptor Protein 3 Inflammasomes Mediating Homocysteine-Induced Insulin Resistance
Sign Up to like & getrecommendations! Published in 2018 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2018.04.022
Abstract: The adipose Nod-like receptor protein 3 (NLRP3) inflammasome senses danger-associated molecular patterns (DAMPs) and initiates insulin resistance, but the mechanisms of adipose inflammasome activation remains elusive. In this study, Homocysteine (Hcy) is revealed to be… read more here.
Keywords: hcy; adipocyte; nod like; resistance ... See more keywords
Nod-Like Receptor Pyrin-Containing Protein 6 (NLRP6) Is Up-regulated in Ileal Crohn’s Disease and Differentially Expressed in Goblet Cells
Sign Up to like & getrecommendations! Published in 2018 at "Cellular and Molecular Gastroenterology and Hepatology"
DOI: 10.1016/j.jcmgh.2018.03.001
Abstract: A contributing factor in the development of ulcerative colitis (UC) and Crohn’s disease (CD) is aberrant signaling of the innate immune complex known as the inflammasome. The inflammasome regulates the production of interleukin (IL)1b and… read more here.
Keywords: protein; goblet; disease; nod like ... See more keywords
Identification of genetic variation in NOD-like receptor 2 gene and influence of polymorphism on gene structure and function in buffalo (Bubalus bubalis).
Sign Up to like & getrecommendations! Published in 2017 at "Research in veterinary science"
DOI: 10.1016/j.rvsc.2017.01.017
Abstract: Nucleotide-binding oligomerization domain (NOD)-like receptor 2 is one of the important mediators of innate as well as adaptive immune response to microbial infections. In this study, NOD-like receptor-2 was characterized by determining the full gene… read more here.
Keywords: analysis; buffalo; nod like; like receptor ... See more keywords
NOD-like receptors: major players (and targets) in the interface between innate immunity and cancer
Sign Up to like & getrecommendations! Published in 2019 at "Bioscience Reports"
DOI: 10.1042/bsr20181709
Abstract: Innate immunity comprises several inflammation-related modulatory pathways which receive signals from an array of membrane-bound and cytoplasmic pattern recognition receptors (PRRs). The NLRs (NACHT (NAIP (neuronal apoptosis inhibitor protein), C2TA (MHC class 2 transcription activator),… read more here.
Keywords: immunity; major players; innate immunity; like receptors ... See more keywords
NOD-like receptor protein 3 inflammasome drives postoperative mechanical pain in a sex-dependent manner.
Sign Up to like & getrecommendations! Published in 2019 at "Pain"
DOI: 10.1097/j.pain.0000000000001555
Abstract: Postoperative pain management continues to be suboptimal due to the lack of effective non-opioid therapies and absence of understanding of sex-driven differences. Here we asked how the NLRP3 inflammasome contributes to postoperative pain. Inflammasomes are… read more here.
Keywords: nod like; postoperative mechanical; sex; postoperative pain ... See more keywords