A cell‐based test system for the assessment of pharmacokinetics of NOD1 and NOD2 receptor agonists
Sign Up to like & getrecommendations! Published in 2018 at "International Immunopharmacology"
DOI: 10.1016/j.intimp.2018.07.037
Abstract: &NA; Agonists of nucleotide oligomerization domain (NOD) 1 and NOD2 receptors represent a promising class of immunostimulants and immunological adjuvants. Here, we describe a cell‐based test system to assess their pharmacokinetics. In this system, NOD1… read more here.
Keywords: pharmacokinetics nod1; system; cell based; nod1 nod2 ... See more keywords
NOD1 and NOD2 Are Potential Therapeutic Targets for Cancer Immunotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Computational Intelligence and Neuroscience"
DOI: 10.1155/2022/2271788
Abstract: The nucleotide oligomerization domain (NOD)-like receptors (NLRs) are a group of intracellular proteins that are essential for controlling the host's innate immune response. The cytosolic nucleotide binding oligomerization domains 1 and 2 receptors (NOD1 and… read more here.
Keywords: role nod1; nod2 potential; nod1 nod2; potential therapeutic ... See more keywords
Expression of TLR2, NOD1, and NOD2 and the NLRP3 Inflammasome in Renal Tubular Epithelial Cells of Male versus Female Mice
Sign Up to like & getrecommendations! Published in 2017 at "Nephron"
DOI: 10.1159/000456016
Abstract: Background: Gender-biased outcomes are associated with acute kidney injury (AKI) and human and animal studies have shown that females are preferentially protected from renal ischemia. However, the reason for this is not known. One clue… read more here.
Keywords: gender; tlr2 nod1; nod1 nod2; expression ... See more keywords
Sensing of the microbiota by NOD1 in mesenchymal stromal cells regulates murine hematopoiesis.
Sign Up to like & getrecommendations! Published in 2017 at "Blood"
DOI: 10.1182/blood-2016-06-723742
Abstract: The microbiota is known to influence the generation of hematopoietic progenitors, although the pathways underlying this process are still poorly understood. NOD1 and NOD2 are intracellular sensors for both Gram-positive and Gram-negative bacteria, but their… read more here.
Keywords: hematopoiesis; mesenchymal stromal; microbiota nod1; stromal cells ... See more keywords
Proteome profiling of triple negative breast cancer cells overexpressing NOD1 and NOD2 receptors unveils molecular signatures of malignant cell proliferation
Sign Up to like & getrecommendations! Published in 2019 at "BMC Genomics"
DOI: 10.1186/s12864-019-5523-6
Abstract: BackgroundTriple negative breast cancer (TNBC) is a malignancy with very poor prognosis, due to its aggressive clinical characteristics and lack of response to receptor-targeted drug therapy. In TNBC, immune-related pathways are typically upregulated and may… read more here.
Keywords: nod1 nod2; tnbc; cell; breast cancer ... See more keywords
Association of CYP2C19, TNF-α, NOD1, NOD2, and PPARγ polymorphisms with peptic ulcer disease enhanced by Helicobacter pylori infection
Sign Up to like & getrecommendations! Published in 2021 at "Saudi Medical Journal"
DOI: 10.15537/smj.2021.1.25654
Abstract: Objectives: To assess the correlation between a number of genetic variations of CYP2C19, TNF-α, NOD1, NOD2, and PPARγ genes with the severity of Helicobacter pylori (H. pylori) infections and peptic ulcers (PU). Methods: A retrospective… read more here.
Keywords: nod2 ppar; association; nod1 nod2; cyp2c19 tnf ... See more keywords
NOD1, NOD2, and NLRC5 Receptors in Antiviral and Antimycobacterial Immunity
Sign Up to like & getrecommendations! Published in 2022 at "Vaccines"
DOI: 10.3390/vaccines10091487
Abstract: The innate immune system recognizes pathogen-associated molecular motifs through pattern recognition receptors (PRRs) that induce inflammasome assembly in macrophages and trigger signal transduction pathways, thereby leading to the transcription of inflammatory cytokine genes. Nucleotide-binding oligomerization… read more here.
Keywords: antimycobacterial immunity; nlrc5 receptors; antiviral antimycobacterial; receptors antiviral ... See more keywords