NOD2 promotes endothelial-to-mesenchymal transition of glomerular endothelial cells via MEK/ERK signaling pathway in diabetic nephropathy.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.01.155
Abstract: Endothelial-to-mesenchymal transition (EndMT) of glomerular vascular endothelial cells (GEnCs) is now considered to play a critical role in diabetic nephropathy (DN). NOD2 is newly discovered to be closely related to DN renal injury. However, the… read more here.
Keywords: mek erk; mesenchymal transition; endothelial mesenchymal; diabetic nephropathy ... See more keywords
NOD2 Influences Trajectories of Intestinal Microbiota Recovery After Antibiotic Perturbation
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Gastroenterology and Hepatology"
DOI: 10.1016/j.jcmgh.2020.03.008
Abstract: Background & Aims Loss-of-function variants in nucleotide-binding oligomerization domain-containing protein 2 (NOD2) impair the recognition of the bacterial cell wall component muramyl-dipeptide and are associated with an increased risk for developing Crohn’s disease. Likewise, exposure… read more here.
Keywords: recovery; microbiota; intestinal microbiota; mice ... See more keywords
Bacterial sensing via neuronal Nod2 regulates appetite and body temperature
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DOI: 10.1126/science.abj3986
Abstract: Gut bacteria influence brain functions and metabolism. We investigated whether this influence can be mediated by direct sensing of bacterial cell wall components by brain neurons. In mice, we found that bacterial peptidoglycan plays a… read more here.
Keywords: nod2; brain; temperature; body temperature ... See more keywords
Blau syndrome NOD2 mutations result in loss of NOD2 cross-regulatory function
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.988862
Abstract: The studies described here provide an analysis of the pathogenesis of Blau syndrome and thereby the function of NOD2 as seen through the lens of its dysfunction resulting from Blau-associated NOD2 mutations in its nucleotide-binding… read more here.
Keywords: cross regulation; nod2 mutations; nod2; cross ... See more keywords
Functional Variant rs3135500 in NOD2 Increases the Risk of Multiple System Atrophy in a Chinese Population
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2018.00150
Abstract: Background: Given the overlap of clinical manifestations and pathological characteristics between Parkinson's disease (PD) and multiple system atrophy (MSA), we investigated the associations between five functional polymorphisms of nucleotide-binding oligomerization domain protein 2 (NOD2) which… read more here.
Keywords: system atrophy; rs3135500; chinese population; nod2 ... See more keywords