First in-human radiation dosimetry of 68Ga-NODAGA-RGDyK
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DOI: 10.1186/s13550-017-0288-x
Abstract: BackgroundIntegrin-targeting radiopharmaceuticals have potential broad applications, spanning from cancer theranostics to cardiovascular diseases. We have previously reported preclinical dosimetry results of 68Ga-NODAGA-RGDyK in mice. This study presents the first human dosimetry of 68Ga-NODAGA-RGDyK in the… read more here.
Keywords: nodaga rgdyk; dosimetry; first human; dosimetry 68ga ... See more keywords
Comparison of absorbed dose extrapolation methods for mouse-to-human translation of radiolabelled macromolecules
Sign Up to like & getrecommendations! Published in 2022 at "EJNMMI Research"
DOI: 10.1186/s13550-022-00893-z
Abstract: Background Extrapolation of human absorbed doses (ADs) from biodistribution experiments on laboratory animals is used to predict the efficacy and toxicity profiles of new radiopharmaceuticals. Comparative studies between available animal-to-human dosimetry extrapolation methods are missing.… read more here.
Keywords: extrapolation; organ specific; extrapolation methods; nodaga rgdyk ... See more keywords