Interplay between Lefty and Nodal signaling is essential for the organizer and axial formation in amphioxus embryos.
Sign Up to like & getrecommendations! Published in 2019 at "Developmental biology"
DOI: 10.1016/j.ydbio.2019.08.006
Abstract: The organizer is an essential signaling center required for axial formation during vertebrate embryonic development. In the basal chordate amphioxus, the dorsal blastopore lip of the gastrula has been proposed to be homologous to the… read more here.
Keywords: organizer; axial formation; amphioxus embryos; lefty nodal ... See more keywords
Implication of rare genetic variants of NODAL and ACVR1B in Congenital Heart Disease patients from Indian Population.
Sign Up to like & getrecommendations! Published in 2021 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2021.112869
Abstract: NODAL signaling plays an essential role in vertebrate embryonic patterning and heart development. Accumulating evidences suggest that genetic mutations in TGF-β/NODAL signaling pathway can cause congenital heart disease in humans. To investigate the implication of… read more here.
Keywords: heart; heart disease; nodal acvr1b; congenital heart ... See more keywords
Genetic and Molecular Analyses indicate independent effects of TGIFs on Nodal and Gli3 in neural tube patterning
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Human Genetics"
DOI: 10.1038/ejhg.2016.164
Abstract: Holoprosencephaly (HPE) is a prevalent craniofacial developmental disorder that has both genetic and environmental causes. The gene encoding TG-interacting factor 1 (TGIF1) is among those that are routinely screened in HPE patients. However, the mechanisms… read more here.
Keywords: genetic molecular; independent effects; hpe; tgifs nodal ... See more keywords
Zfp281 is essential for mouse epiblast maturation through transcriptional and epigenetic control of Nodal signaling
Sign Up to like & getrecommendations! Published in 2017 at "eLife"
DOI: 10.7554/elife.33333
Abstract: Pluripotency is defined by a cell's potential to differentiate into any somatic cell type. How pluripotency is transited during embryo implantation, followed by cell lineage specification and establishment of the basic body plan, is poorly… read more here.
Keywords: epigenetic control; epiblast maturation; mouse; nodal signaling ... See more keywords
Cdon mutation and fetal alcohol converge on Nodal signaling in a mouse model of holoprosencephaly
Sign Up to like & getrecommendations! Published in 2020 at "eLife"
DOI: 10.7554/elife.60351
Abstract: Holoprosencephaly (HPE), a defect in midline patterning of the forebrain and midface, arises ~1 in 250 conceptions. It is associated with predisposing mutations in the Nodal and Hedgehog (HH) pathways, with penetrance and expressivity graded… read more here.
Keywords: nodal signaling; model; cdon mutation; fetal alcohol ... See more keywords
Regulation of Nodal signaling propagation by receptor interactions and positive feedback
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.66397
Abstract: During vertebrate embryogenesis, the germ layers are patterned by secreted Nodal signals. In the classical model, Nodals elicit signaling by binding to a complex comprising Type I/II Activin receptors (Acvr) and the co-receptor Tdgf1. However,… read more here.
Keywords: signaling propagation; type; nodal signaling; propagation receptor ... See more keywords