Influence of Nodal signalling on pluripotency factor expression, tumour cell proliferation and cisplatin-sensitivity in testicular germ cell tumours
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DOI: 10.1186/s12885-020-06820-6
Abstract: Background Testicular germ cell tumours (TGCTs) are characterised by an overall high cisplatin-sensitivity which has been linked to their continued expression of pluripotency factors. Recently, the Nodal signalling pathway has been implicated in the regulation… read more here.
Keywords: cisplatin sensitivity; nodal signalling; pluripotency; expression ... See more keywords
Role of Nodal signalling in testis development and initiation of testicular cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Reproduction"
DOI: 10.1530/rep-18-0641
Abstract: Testicular development from the initially bipotential gonad is a tightly regulated process involving a complex signalling cascade to ensure proper sequential expression of signalling factors and secretion of steroid hormones. Initially, Sertoli cell specification facilitates… read more here.
Keywords: development; testis development; cell; nodal signalling ... See more keywords