Systemic and cerebrospinal fluid immune and complement activation in Ugandan children and adolescents with long‐standing nodding syndrome: A case‐control study
Sign Up to like & getrecommendations! Published in 2020 at "Epilepsia Open"
DOI: 10.1002/epi4.12463
Abstract: Nodding syndrome is a poorly understood epileptic encephalopathy characterized by a unique seizure type—head nodding—and associated with Onchocerca volvulus infection. We hypothesized that altered immune activation in the cerebrospinal fluid (CSF) and plasma of children… read more here.
Keywords: nodding syndrome; systemic cerebrospinal; fluid immune; activation ... See more keywords
Nodding syndrome in Uganda is a tauopathy
Sign Up to like & getrecommendations! Published in 2018 at "Acta Neuropathologica"
DOI: 10.1007/s00401-018-1909-9
Abstract: Nodding syndrome is an epidemic neurologic disorder of unknown cause that affects children in the subsistence-farming communities of East Africa. We report the neuropathologic findings in five fatal cases (13–18 years of age at death) of… read more here.
Keywords: uganda tauopathy; nodding syndrome; syndrome uganda;
Closing the Loop between Nodding Syndrome and Onchocerca Infection.
Sign Up to like & getrecommendations! Published in 2017 at "Trends in parasitology"
DOI: 10.1016/j.pt.2017.05.002
Abstract: We thank Spencer et al. for their interest in our study [1] and for the additional information about how the cases in Tanzania may differ from those with nodding syndrome in South Sudan and Uganda.… read more here.
Keywords: nodding syndrome; infection; closing loop; loop nodding ... See more keywords
The spectrum of disease and tau pathology of nodding syndrome in Uganda
Sign Up to like & getrecommendations! Published in 2022 at "Brain"
DOI: 10.1093/brain/awac137
Abstract: Abstract Nodding syndrome is an enigmatic recurrent epidemic neurologic disease that affects children in East Africa. The illness begins with vertical nodding of the head and can progress to grand mal seizures and death after… read more here.
Keywords: pathology; tau pathology; nodding syndrome; spectrum disease ... See more keywords
Dried blood microsampling-based therapeutic drug monitoring of anti-epileptic drugs in children with nodding syndrome and epilepsy in Uganda and the Democratic Republic of the Congo.
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DOI: 10.1097/ftd.0000000000000720
Abstract: Nodding syndrome is a highly debilitating, generalized seizure disorder, affecting children in subregions of sub-Saharan Africa. Despite numerous efforts to uncover the etiology, the exact cause of this syndrome still remains obscure. Therefore, to date,… read more here.
Keywords: epilepsy; dried blood; nodding syndrome; therapeutic drug ... See more keywords
Link to Alzheimer's seen in nodding syndrome.
Sign Up to like & getrecommendations! Published in 2018 at "Science"
DOI: 10.1126/science.362.6421.1341
Abstract: A disease mystery with no shortage of leads now has an intriguing new one. Since the 1960s, thousands of children in poor, war-torn regions of East Africa have developed epilepsy-like seizures in which their heads… read more here.
Keywords: nodding syndrome; link alzheimer; seen nodding; alzheimer seen ... See more keywords
Nodding syndrome: Preventable and treatable
Sign Up to like & getrecommendations! Published in 2017 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aam8532
Abstract: New insights into the pathophysiology of nodding syndrome, a form of childhood epilepsy associated with onchocerciasis, provide new opportunities for disease treatment and parasite control (Johnson et al.). New insights into the pathophysiology of nodding… read more here.
Keywords: medicine; nodding syndrome; preventable treatable; syndrome preventable ... See more keywords
‘There Were Moments We Wished She Could Just Die’: The Highly Gendered Burden of Nodding Syndrome in Northern Uganda
Sign Up to like & getrecommendations! Published in 2022 at "Qualitative Health Research"
DOI: 10.1177/10497323221085941
Abstract: Nodding Syndrome (NS) occurs within a wide spectrum of epilepsies seen in onchocerciasis endemic areas of sub-Saharan Africa. It has debilitating consequences on affected individuals and increases the socio-economic, physical and psychological burden on care-givers… read more here.
Keywords: moments wished; northern uganda; nodding syndrome; could die ... See more keywords
Doxycycline for the treatment of nodding syndrome (DONS); the study protocol of a phase II randomised controlled trial
Sign Up to like & getrecommendations! Published in 2019 at "BMC Neurology"
DOI: 10.1186/s12883-019-1256-z
Abstract: BackgroundNodding syndrome is a poorly understood neurological disorder of unknown aetiology, affecting several thousand children in Africa. There has been a consistent epidemiological association with infection by the filarial parasite, Onchocerca volvulus and antibodies to… read more here.
Keywords: phase; nodding syndrome; trial; treatment nodding ... See more keywords
Is nodding syndrome in northern Uganda linked to consumption of mycotoxin contaminated food grains?
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DOI: 10.1186/s13104-018-3774-y
Abstract: ObjectiveNodding syndrome (NS) is a type of epilepsy characterized by repeated head-nodding seizures that appear in previously healthy children between 3 and 18 years of age. In 2012, during a WHO International Meeting on NS in… read more here.
Keywords: nodding syndrome; syndrome northern; northern uganda; uganda ... See more keywords
"Those who died are the ones that are cured". Walking the political tightrope of Nodding Syndrome in northern Uganda: Emerging challenges for research and policy
Sign Up to like & getrecommendations! Published in 2019 at "PLoS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0007344
Abstract: Background Nodding Syndrome was first reported from Tanzania in the 1960s but appeared as an epidemic in Northern Uganda in the 1990s during the LRA civil war. It is characterized by repetitive head nodding, often… read more here.
Keywords: nodding syndrome; research; prevention treatment; northern uganda ... See more keywords