Chemical Replacement of Noggin with Dorsomorphin Homolog 1 for Cost-Effective Direct Neuronal Conversion
Sign Up to like & getrecommendations! Published in 2022 at "Cellular Reprogramming"
DOI: 10.1089/cell.2021.0200
Abstract: The direct conversion of adult human skin fibroblasts (FBs) into induced neurons (iNs) represents a useful technology to generate donor-specific adult-like human neurons. Disease modeling studies rely on the consistently efficient conversion of relatively large… read more here.
Keywords: noggin; conversion; dorsomorphin homolog; dmh1 ... See more keywords
Noggin proteins are multifunctional extracellular regulators of cell signaling
Sign Up to like & getrecommendations! Published in 2022 at "Genetics"
DOI: 10.1093/genetics/iyac049
Abstract: Abstract Noggin is an extracellular cysteine knot protein that plays a crucial role in vertebrate dorsoventral patterning. Noggin binds and inhibits the activity of bone morphogenetic proteins via a conserved N-terminal clip domain. Noncanonical orthologs… read more here.
Keywords: noggin; receptor tyrosine; bone morphogenic; tyrosine kinase ... See more keywords