Navigating Homogeneous Graph Paths Through Amyloidogenic and Non‐Amyloidogenic Hexapeptides
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Computational Chemistry"
DOI: 10.1002/jcc.70238
Abstract: Hexapeptides are increasingly applied as model systems for studying the amyloidogenic properties of oligo‐ and polypeptides. It is possible to construct 64 million different hexapeptides from the twenty proteinogenic amino acid residues. Today's experimental amyloid… read more here.
Keywords: predictor; amyloidogenic hexapeptides; amyloidogenic non; non amyloidogenic ... See more keywords
Formononetin attenuates Aβ25-35-induced cytotoxicity in HT22 cells via PI3K/Akt signaling and non-amyloidogenic cleavage of APP
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2016.12.064
Abstract: Amyloid beta (Aβ) is the main component of the amyloid plaques that accumulate in the brains of Alzheimer patients. Here, we reported the protective role of Formononetin (Form) against Aβ25-35-induced neurotoxicity in HT22 cells. We… read more here.
Keywords: ht22; akt signaling; pi3k akt; ht22 cells ... See more keywords
The Alzheimer's Disease "non-amyloidogenic" p3 peptide revisited: a case for Amyloid-α.
Sign Up to like & getrecommendations! Published in 2020 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.0c00160
Abstract: Amyloid-β (Aβ) is an intrinsically disordered peptide thought to play an important role in Alzheimer's Disease. It has been the target of most AD therapeutic efforts, which have repeatedly failed in clinical trials. A more… read more here.
Keywords: alzheimer disease; peptide; non amyloidogenic;
Analysis of Non-Amyloidogenic Mutations in APP Supports Loss of Function Hypothesis of Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24032092
Abstract: Proteolytic processing of amyloid precursor protein (APP) plays a critical role in pathogenesis of Azheimer’s disease (AD). Sequential cleavage of APP by β- and γ-secretases leads to generation of Aβ40 (non-amyloidogenic) and Aβ42 (amyloidogenic) peptides.… read more here.
Keywords: function; non amyloidogenic; hypothesis; loss ... See more keywords