Formononetin attenuates Aβ25-35-induced cytotoxicity in HT22 cells via PI3K/Akt signaling and non-amyloidogenic cleavage of APP
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2016.12.064
Abstract: Amyloid beta (Aβ) is the main component of the amyloid plaques that accumulate in the brains of Alzheimer patients. Here, we reported the protective role of Formononetin (Form) against Aβ25-35-induced neurotoxicity in HT22 cells. We… read more here.
Keywords: ht22; akt signaling; pi3k akt; ht22 cells ... See more keywords
The Alzheimer's Disease "non-amyloidogenic" p3 peptide revisited: a case for Amyloid-α.
Sign Up to like & getrecommendations! Published in 2020 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.0c00160
Abstract: Amyloid-β (Aβ) is an intrinsically disordered peptide thought to play an important role in Alzheimer's Disease. It has been the target of most AD therapeutic efforts, which have repeatedly failed in clinical trials. A more… read more here.
Keywords: alzheimer disease; peptide; non amyloidogenic;
Analysis of Non-Amyloidogenic Mutations in APP Supports Loss of Function Hypothesis of Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24032092
Abstract: Proteolytic processing of amyloid precursor protein (APP) plays a critical role in pathogenesis of Azheimer’s disease (AD). Sequential cleavage of APP by β- and γ-secretases leads to generation of Aβ40 (non-amyloidogenic) and Aβ42 (amyloidogenic) peptides.… read more here.
Keywords: function; non amyloidogenic; hypothesis; loss ... See more keywords