Optogenetic Control of Non‐Apoptotic Cell Death
Sign Up to like & getrecommendations! Published in 2021 at "Advanced Science"
DOI: 10.1002/advs.202100424
Abstract: Abstract Herein, a set of optogenetic tools (designated LiPOP) that enable photoswitchable necroptosis and pyroptosis in live cells with varying kinetics, is introduced. The LiPOP tools allow reconstruction of the key molecular steps involved in… read more here.
Keywords: non apoptotic; apoptotic cell; cell death; optogenetic control ... See more keywords
Orai1 is an Entotic Ca2+ Channel for Non‐Apoptotic Cell Death, Entosis in Cancer Development
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202205913
Abstract: Entosis is a non‐apoptotic cell death process that forms characteristic cell‐in‐cell structures in cancers, killing invading cells. Intracellular Ca2+ dynamics are essential for cellular processes, including actomyosin contractility, migration, and autophagy. However, the significance of… read more here.
Keywords: cell death; non apoptotic; apoptotic cell; entosis ... See more keywords
Guangsangon E triggers mitochondria dysfunction and mitophagy in triple‐negative breast cancer and leads to non‐apoptotic cell death
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23463
Abstract: Guangsangon E (GSE) is a natural product separated from Morus alba L. It has been reported to treat lung cancer through autophagy. However, whether GSE is effective in repressing triple‐negative breast cancer (TNBC) cells is… read more here.
Keywords: cell; non apoptotic; triple negative; breast cancer ... See more keywords
Stimulation of chemokines in human endometrial stromal cells by tumor necrosis factor-α and interferon-γ is similar under apoptotic and non-apoptotic conditions
Sign Up to like & getrecommendations! Published in 2017 at "Archives of Gynecology and Obstetrics"
DOI: 10.1007/s00404-017-4586-3
Abstract: PurposeTumor necrosis factor (TNF)-α and interferon (IFN)-γ are pro-inflammatory cytokines which have been shown to be involved in the pathophysiology of implantation disorders. Both cytokines in combination are able to sensitize primarily resistant human endometrial… read more here.
Keywords: non apoptotic; stimulation; human endometrial; endometrial stromal ... See more keywords
Lysosomal Machinery Drives Extracellular Acidification to Direct Non-apoptotic Cell Death
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.03.034
Abstract: SUMMARY Cell death is a fundamental aspect of development, homeostasis, and disease; yet, our understanding of non-apoptotic forms of cell death is limited. One such form is phagoptosis, in which one cell utilizes phagocytosis machinery… read more here.
Keywords: death; non apoptotic; lysosomal machinery; cell death ... See more keywords
Coupled Caspase and N-End Rule Ligase Activities Allow Recognition and Degradation of Pluripotency Factor LIN-28 during Non-Apoptotic Development.
Sign Up to like & getrecommendations! Published in 2017 at "Developmental cell"
DOI: 10.1016/j.devcel.2017.05.013
Abstract: Recent findings suggest that components of the classical cell death machinery also have important non-cell-death (non-apoptotic) functions in flies, nematodes, and mammals. However, the mechanisms for non-canonical caspase substrate recognition and proteolysis, and the direct… read more here.
Keywords: pluripotency factor; lin; non apoptotic; end rule ... See more keywords
Unsaturated Fatty Acid Liposomes Selectively Regulate Glutathione Peroxidase 4 to Exacerbate Lipid Peroxidation as an Adaptable Liposome Platform for Anti-Tumor Therapy.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00642
Abstract: Regulating non-apoptotic cell death of cancer cells provides a promising strategy to overcome apoptosis resistance during cancer treatment. Lipids are essential components to exacerbate several non-apoptotic cell death pathways. In the present study, unsaturated fatty… read more here.
Keywords: non apoptotic; lipid peroxidation; anti tumor; tumor ... See more keywords
Turning the Spotlight on Lipids in Non-Apoptotic Cell Death.
Sign Up to like & getrecommendations! Published in 2018 at "ACS chemical biology"
DOI: 10.1021/acschembio.7b01082
Abstract: Although apoptosis has long dominated the spotlight, studies in the past two decades have expanded the repertoire of programmed cell death (PCD). Several forms of non-apoptotic regulated cell death have been identified, with important links… read more here.
Keywords: forms non; pcd; non apoptotic; cell death ... See more keywords
Selecting motile, non-apoptotic and induced spermatozoa for capacitation without centrifuging by MACS-Up method.
Sign Up to like & getrecommendations! Published in 2022 at "Andrologia"
DOI: 10.1111/and.14405
Abstract: In newly improved MACS-Up method, magnetic field has been applied to separate non-apoptotic spermatozoa directly from the neat semen. The spermatozoa during passing through a viscous layer, located on the neat semen, contacted with progesterone… read more here.
Keywords: capacitation; non apoptotic; macs method; method ... See more keywords
Identification of a signature based on non‐apoptotic regulatory cell death to improve prognosis prediction in acute myeloid leukaemia
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Haematology"
DOI: 10.1111/bjh.18601
Abstract: Although anti‐apoptotic cell death is a common feature of cancer and non‐apoptotic regulatory cell death (RCD) is highly correlated with cancer progression and response to therapy, its prognostic role in patients with acute myeloid leukaemia… read more here.
Keywords: cell death; non apoptotic; cell; apoptotic regulatory ... See more keywords
Ferroptosis: bug or feature?
Sign Up to like & getrecommendations! Published in 2017 at "Immunological Reviews"
DOI: 10.1111/imr.12533
Abstract: Ferroptosis is an iron‐dependent, oxidative form of non‐apoptotic cell death. This form of cell death does not share morphological, biochemical, or genetic similarities with classic necrosis, necroptosis, parthanatos, or other forms of non‐apoptotic cell death.… read more here.
Keywords: ferroptosis; ferroptosis bug; non apoptotic; cell death ... See more keywords