Measuring Repeat-Associated Non-AUG (RAN) Translation.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1975-9_8
Abstract: Expansions of short nucleotide repeats account for more than 50 neurological or neuromuscular diseases. Many repeat expansion-containing RNAs can generate toxic repeat proteins through repeat-associated non-AUG (RAN) translation in all the reading frames. Understanding how… read more here.
Keywords: repeat associated; associated non; ran translation; non aug ... See more keywords
Non-AUG start codons: Expanding and regulating the small and alternative ORFeome.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2020.111973
Abstract: Recent ribosome profiling and proteomic studies have revealed the presence of thousands of novel coding sequences, referred to as small open reading frames (sORFs), in prokaryotic and eukaryotic genomes. These genes have defied discovery via… read more here.
Keywords: non aug; start codons; aug start; codons expanding ... See more keywords
Non-canonical initiation factors modulate repeat-associated non-AUG translation.
Sign Up to like & getrecommendations! Published in 2022 at "Human molecular genetics"
DOI: 10.1093/hmg/ddac021
Abstract: Repeat associated non-AUG (RAN) translation of expanded repeat mutation mRNA produces toxic peptides in neurons of patients suffering from neurodegenerative diseases. Recent findings indicate that RAN translation in diverse model systems is not inhibited by… read more here.
Keywords: associated non; repeat; repeat associated; non aug ... See more keywords
Competition between translation initiation factor eIF5 and its mimic protein 5MP determines non-AUG initiation rate genome-wide
Sign Up to like & getrecommendations! Published in 2017 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkx808
Abstract: Abstract In the human genome, translation initiation from non-AUG codons plays an important role in various gene regulation programs. However, mechanisms regulating the non-AUG initiation rate remain poorly understood. Here, we show that the non-AUG… read more here.
Keywords: initiation rate; initiation; non aug; aug initiation ... See more keywords
Translational recoding by chemical modification of non-AUG start codon ribonucleotide bases.
Sign Up to like & getrecommendations! Published in 2022 at "Science advances"
DOI: 10.1126/sciadv.abm8501
Abstract: In contrast to prokaryotes wherein GUG and UUG are permissive start codons, initiation frequencies from non-AUG codons are generally low in eukaryotes, with CUG being considered as strongest. Here, we report that combined 5-cytosine methylation… read more here.
Keywords: start codon; chemical; non aug; aug start ... See more keywords