A New Bias Site for Epigenetic Modifications: How Non‐Canonical GC Base Pairs Favor Mechanochemical Cleavage of DNA
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DOI: 10.1002/bies.202000051
Abstract: Properties of non‐canonical GC base pairs and their relations with mechanochemical cleavage of DNA are analyzed. A hypothesis of the involvement of the transient GC wobble base pairs both in the mechanisms of the mechanochemical… read more here.
Keywords: base pairs; non canonical; base; cleavage dna ... See more keywords
The complex web of canonical and non‐canonical Hedgehog signaling
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DOI: 10.1002/bies.202100183
Abstract: Hedgehog (Hh) signaling is a widely studied signaling pathway because of its critical roles during development and in cell homeostasis. Vertebrate canonical and non‐canonical Hh signaling are typically assumed to be distinct and occur in… read more here.
Keywords: hedgehog signaling; canonical non; non canonical; complex web ... See more keywords
Non‐canonical bivalent H3K4me3K9me3 recognition by Spindlin1/C11orf84 complex
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DOI: 10.1002/bies.202100229
Abstract: Bivalent chromatin with active H3K4me3 and repressive H3K27me3 was initially identified in embryonic stem cells (ESCs) to poise expression of developmental genes upon lineage commitment. Since then, many more different bivalent modifications have been demonstrated… read more here.
Keywords: spindlin1 c11orf84; non canonical; bivalent; c11orf84 complex ... See more keywords
Understanding the role of non‐Watson‐Crick base pairs in DNA–protein recognition: Structural and energetic aspects using crystallographic database analysis and quantum chemical calculation
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DOI: 10.1002/bip.23492
Abstract: Specific recognition of DNA base sequences by proteins is vital for life‐cycles of all organisms. In a large number of crystal structures of protein–DNA complexes, DNA conformation significantly deviates from the canonical B‐DNA structure. A… read more here.
Keywords: dna; base pairs; canonical base; non canonical ... See more keywords
Site‐specifically Incorporated Non‐Canonical Amino Acids into Pseudomonas alcaligenes Lipase to Hydrolyze L‐menthol Propionate among the Eight Isomers
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DOI: 10.1002/cctc.202100358
Abstract: It remains a challenge to improve the diastereopreference of enzymes when there are multiple chiral centers in the substrate, mainly because the limited understanding of mechanism determining diastereoselectivity. Compared with natural amino acids, non‐canonical amino… read more here.
Keywords: non canonical; canonical amino; amino acids; menthol propionate ... See more keywords
Canonical and non‐canonical functions of STAT in germline stem cell maintenance
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DOI: 10.1002/dvdy.576
Abstract: Maintenance of the Drosophila male germline stem cells (GSCs) requires activation of the Janus kinase/signal transducer and activators of transcription (JAK/STAT) pathway by niche signals. The precise role of JAK/STAT signaling in GSC maintenance, however,… read more here.
Keywords: canonical functions; canonical non; maintenance; non canonical ... See more keywords
A non‐canonical tumor suppressive role for the long non‐coding RNA MALAT1 in colon and breast cancers
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DOI: 10.1002/ijc.31386
Abstract: Long noncoding RNAs (lncRNAs) constitute one of the largest classes of transcripts and have been widely implicated in various diseases such as cancer. Increasing evidence suggests that several lncRNAs are dysregulated and play critical roles… read more here.
Keywords: colon breast; malat1; breast cancers; non canonical ... See more keywords
The non‐canonical nuclear functions of key players of the PI3K‐AKT‐MTOR pathway
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DOI: 10.1002/jcp.30782
Abstract: The PI3K‐AKT‐MTOR signal transduction pathway is one of the essential signalling cascades within the cell due to its involvement in many vital functions. The pathway initiates with the recruitment of phosphatidylinositol‐3 kinases (PI3Ks) onto the… read more here.
Keywords: pi3k akt; nuclear functions; akt mtor; non canonical ... See more keywords
From Folding to Assembly: Functional Supramolecular Architectures of Peptides Comprised of Non-Canonical Amino Acids.
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DOI: 10.1002/mabi.202100090
Abstract: The engineering of biological molecules is the fundamental concept behind the design of complex materials with desirable functions. Over the last few decades, peptides and proteins have emerged as useful building blocks for well-defined nanostructures… read more here.
Keywords: amino acids; folding assembly; non canonical; canonical amino ... See more keywords
Ursolic acid inhibits the activation of smoothened‐independent non‐canonical hedgehog pathway in colorectal cancer by suppressing AKT signaling cascade
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DOI: 10.1002/ptr.7523
Abstract: It is being brought to light that smoothened (SMO)‐independent non‐canonical Hedgehog signaling is associated with the pathogenesis of various cancers. Ursolic acid (UA), a pentacyclic triterpenoid present in many medicinal herbs, manifests potent effectiveness against… read more here.
Keywords: signaling cascade; hedgehog; crc; non canonical ... See more keywords
Interaction of Epac with Non-canonical Cyclic Nucleotides.
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DOI: 10.1007/164_2015_37
Abstract: Epac1 and Epac2 are cyclic nucleotide-binding (CNB) domain containing proteins, which were originally identified as cAMP-regulated guanine nucleotide exchange factors (GEFs) for the small G-protein Rap. Therefore, Epac proteins founded next to protein kinase A… read more here.
Keywords: epac non; interaction epac; non canonical; cyclic nucleotides ... See more keywords