Design, synthesis and biological evaluation of some tetrazole acetamide derivatives as novel non-carboxylic PTP1B inhibitors.
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DOI: 10.1016/j.bioorg.2019.103221
Abstract: A series of ten N-(3-(1H-tetrazole-5-yl)phenyl)acetamide derivatives (NM-07 to NM-16) designed from a lead molecule identified previously in our laboratory were synthesized and evaluated for protein tyrosine phosphatase 1B (PTP1B) inhibitory activity. Among the synthesized molecules,… read more here.
Keywords: design synthesis; acetamide derivatives; biological evaluation; novel non ... See more keywords