Mutant TDP-43 Expression Triggers TDP-43 Pathology and Cell Autonomous Effects on Primary Astrocytes: Implications for Non-cell Autonomous Pathology in ALS
Sign Up to like & getrecommendations! Published in 2020 at "Neurochemical Research"
DOI: 10.1007/s11064-020-03048-5
Abstract: Motor neuron degeneration in amyotrophic lateral sclerosis (ALS) caused by mutations in superoxide dismutase 1 (SOD1) is partly non-cell autonomous, involving cellular dysfunction of astrocytes. Whether non-cell autonomous effects occur in other forms of ALS,… read more here.
Keywords: mutant tdp; tdp; non cell; pathology ... See more keywords
Interleukin 17 selectively predicts better outcomes with bupropion-SSRI combination: Novel T cell biomarker for antidepressant medication selection
Sign Up to like & getrecommendations! Published in 2017 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2017.07.005
Abstract: BACKGROUND Interleukin 17 (IL-17) is produced by highly inflammatory Th17 cells and has been implicated in pathophysiology of depression. IL-17 putatively disrupts the blood brain barrier and affects dopamine synthesis whereas dopamine has been shown… read more here.
Keywords: treatment; non cell; ssri combination; cell markers ... See more keywords
Non-cell-autonomous disruption of nuclear architecture as a potential cause of COVID-19-induced anosmia
Sign Up to like & getrecommendations! Published in 2022 at "Cell"
DOI: 10.1016/j.cell.2022.01.024
Abstract: SARS-CoV-2 infects less than 1% of cells in the human body, yet it can cause severe damage in a variety of organs. Thus, deciphering the non-cell autonomous effects of SARS-CoV-2 infection is imperative for understanding… read more here.
Keywords: sars cov; cell autonomous; non cell; disruption ... See more keywords
CRISPR/Cas9 system-mediated impairment of synaptobrevin/VAMP function in postmitotic hippocampal neurons
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neuroscience Methods"
DOI: 10.1016/j.jneumeth.2016.12.015
Abstract: BACKGROUND The use of the CRISPR/Cas9 system is becoming widespread, however current studies have predominantly focused on dividing cells. It is currently unknown if CRISPR/Cas9 can be used in a postmitotic setting to examine non-cell… read more here.
Keywords: crispr cas9; non cell; cas9 system; cell autonomous ... See more keywords
Non-cell-autonomous pathogenic mechanisms in amyotrophic lateral sclerosis
Sign Up to like & getrecommendations! Published in 2021 at "Trends in Neurosciences"
DOI: 10.1016/j.tins.2021.04.008
Abstract: Amyotrophic lateral sclerosis (ALS) is the most common adult-onset paralytic disorder, characterized mainly by a loss of motor neurons (MNs) in the CNS. Over the past decades, thanks to intense investigations performed in both in… read more here.
Keywords: non cell; amyotrophic lateral; cell autonomous; autonomous pathogenic ... See more keywords
Cell- and non-cell-autonomous AUXIN RESPONSE FACTOR3 controls meristem proliferation and phyllotactic patterns.
Sign Up to like & getrecommendations! Published in 2022 at "Plant physiology"
DOI: 10.1093/plphys/kiac370
Abstract: In cell-cell communication, non-cell-autonomous transcription factors play vital roles in controlling plant stem cell fate. We previously reported that AUXIN RESPONSE FACTOR3 (ARF3), a member of the ARF family with critical roles in floral meristem… read more here.
Keywords: cell; response factor3; auxin response; cell autonomous ... See more keywords
Neonatal apneic phenotype in a murine congenital central hypoventilation syndrome model is induced through non‐cell autonomous developmental mechanisms
Sign Up to like & getrecommendations! Published in 2020 at "Brain Pathology"
DOI: 10.1111/bpa.12877
Abstract: Congenital central hypoventilation syndrome (CCHS) represents a rare genetic disorder usually caused by mutations in the homeodomain transcription factor PHOX2B. Some CCHS patients suffer mainly from deficiencies in CO2 and/or O2 respiratory chemoreflex, whereas other… read more here.
Keywords: murine; congenital central; visceral motor; non cell ... See more keywords
Non–cell-autonomous regulation of interneuron specification mediated by extracellular vesicles
Sign Up to like & getrecommendations! Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.add8164
Abstract: Disruption in neurogenesis and neuronal migration can influence the assembly of cortical circuits, affecting the excitatory-inhibitory balance and resulting in neurodevelopmental and neuropsychiatric disorders. Using ventral cerebral organoids and dorsoventral cerebral assembloids with mutations in… read more here.
Keywords: extracellular vesicles; cell autonomous; autonomous regulation; non cell ... See more keywords
Abstract 3754: The cell- and non-cell autonomous actions of UCA1 dysregulation in hypopharyngeal cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3754
Abstract: Long non-coding RNAs (lncRNAs), encoding noncoding transcripts greater than 200 nucleotides, are multifunctional regulator of gene expression and play vital roles in various biological processes. Urothelial cancer-associated 1 (UCA1) is one such molecule and found… read more here.
Keywords: cell; non cell; cell non; hypopharyngeal cancer ... See more keywords
miR-125b promotes MLL-AF9-driven murine acute myeloid leukemia involving a VEGFA-mediated non-cell-intrinsic mechanism.
Sign Up to like & getrecommendations! Published in 2017 at "Blood"
DOI: 10.1182/blood-2016-06-721027
Abstract: The hematopoietic stem cell-enriched miR-125 family microRNAs (miRNAs) are critical regulators of hematopoiesis. Overexpression of miR-125a or miR-125b is frequent in human acute myeloid leukemia (AML), and the overexpression of these miRNAs in mice leads… read more here.
Keywords: overexpression; mir 125b; non cell; mll af9 ... See more keywords
Transient IKK2 activation in astrocytes initiates selective non-cell-autonomous neurodegeneration
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Neurodegeneration"
DOI: 10.1186/s13024-017-0157-0
Abstract: BackgroundNeuroinflammation is associated with a wide range of neurodegenerative disorders, however the specific contribution to individual disease pathogenesis and selective neuronal cell death is not well understood. Inflammatory cerebellar ataxias are neurodegenerative diseases occurring in… read more here.
Keywords: neurodegeneration; ikk2 activation; cell; non cell ... See more keywords