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   Articles with "non cell" as a keyword



The multidrug and toxin extrusion (MATE) transporter DTX51 antagonizes non‐cell‐autonomous HLS1–AMP1 signaling in a region‐specific manner

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recommendations! Published in 2025 at "Febs Letters"

DOI: 10.1002/1873-3468.70134

Abstract: Multidrug and toxin extrusion (MATE) transporters are widely conserved across all domains of life and play diverse roles in plant development. Here, we investigated the role of DETOXIFICATION 51 (DTX51), a MATE transporter in Arabidopsis.… read more here.

Keywords: non cell; multidrug toxin; dtx51; toxin extrusion ... See more keywords
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Mutant TDP-43 Expression Triggers TDP-43 Pathology and Cell Autonomous Effects on Primary Astrocytes: Implications for Non-cell Autonomous Pathology in ALS

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recommendations! Published in 2020 at "Neurochemical Research"

DOI: 10.1007/s11064-020-03048-5

Abstract: Motor neuron degeneration in amyotrophic lateral sclerosis (ALS) caused by mutations in superoxide dismutase 1 (SOD1) is partly non-cell autonomous, involving cellular dysfunction of astrocytes. Whether non-cell autonomous effects occur in other forms of ALS,… read more here.

Keywords: mutant tdp; tdp; non cell; pathology ... See more keywords

Interleukin 17 selectively predicts better outcomes with bupropion-SSRI combination: Novel T cell biomarker for antidepressant medication selection

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recommendations! Published in 2017 at "Brain, Behavior, and Immunity"

DOI: 10.1016/j.bbi.2017.07.005

Abstract: BACKGROUND Interleukin 17 (IL-17) is produced by highly inflammatory Th17 cells and has been implicated in pathophysiology of depression. IL-17 putatively disrupts the blood brain barrier and affects dopamine synthesis whereas dopamine has been shown… read more here.

Keywords: treatment; non cell; ssri combination; cell markers ... See more keywords
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Non-cell-autonomous disruption of nuclear architecture as a potential cause of COVID-19-induced anosmia

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recommendations! Published in 2022 at "Cell"

DOI: 10.1016/j.cell.2022.01.024

Abstract: SARS-CoV-2 infects less than 1% of cells in the human body, yet it can cause severe damage in a variety of organs. Thus, deciphering the non-cell autonomous effects of SARS-CoV-2 infection is imperative for understanding… read more here.

Keywords: sars cov; cell autonomous; non cell; disruption ... See more keywords

CRISPR/Cas9 system-mediated impairment of synaptobrevin/VAMP function in postmitotic hippocampal neurons

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recommendations! Published in 2017 at "Journal of Neuroscience Methods"

DOI: 10.1016/j.jneumeth.2016.12.015

Abstract: BACKGROUND The use of the CRISPR/Cas9 system is becoming widespread, however current studies have predominantly focused on dividing cells. It is currently unknown if CRISPR/Cas9 can be used in a postmitotic setting to examine non-cell… read more here.

Keywords: crispr cas9; non cell; cas9 system; cell autonomous ... See more keywords
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Non-cell-autonomous pathogenic mechanisms in amyotrophic lateral sclerosis

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recommendations! Published in 2021 at "Trends in Neurosciences"

DOI: 10.1016/j.tins.2021.04.008

Abstract: Amyotrophic lateral sclerosis (ALS) is the most common adult-onset paralytic disorder, characterized mainly by a loss of motor neurons (MNs) in the CNS. Over the past decades, thanks to intense investigations performed in both in… read more here.

Keywords: non cell; amyotrophic lateral; cell autonomous; autonomous pathogenic ... See more keywords

Harnessing the potential of hydrogels for advanced therapeutic applications: current achievements and future directions

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recommendations! Published in 2024 at "Signal Transduction and Targeted Therapy"

DOI: 10.1038/s41392-024-01852-x

Abstract: The applications of hydrogels have expanded significantly due to their versatile, highly tunable properties and breakthroughs in biomaterial technologies. In this review, we cover the major achievements and the potential of hydrogels in therapeutic applications,… read more here.

Keywords: cell therapy; non cell; therapeutic applications; potential hydrogels ... See more keywords

Huntington’s disease cellular phenotypes are rescued non-cell autonomously by healthy cells in mosaic telencephalic organoids

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recommendations! Published in 2024 at "Nature Communications"

DOI: 10.1038/s41467-024-50877-x

Abstract: Huntington’s disease (HD) causes selective degeneration of striatal and cortical neurons, resulting in cell mosaicism of coexisting still functional and dysfunctional cells. The impact of non-cell autonomous mechanisms between these cellular states is poorly understood.… read more here.

Keywords: non cell; huntington disease; cell; healthy cells ... See more keywords

Cell- and non-cell-autonomous AUXIN RESPONSE FACTOR3 controls meristem proliferation and phyllotactic patterns.

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recommendations! Published in 2022 at "Plant physiology"

DOI: 10.1093/plphys/kiac370

Abstract: In cell-cell communication, non-cell-autonomous transcription factors play vital roles in controlling plant stem cell fate. We previously reported that AUXIN RESPONSE FACTOR3 (ARF3), a member of the ARF family with critical roles in floral meristem… read more here.

Keywords: cell; response factor3; auxin response; cell autonomous ... See more keywords

Neonatal apneic phenotype in a murine congenital central hypoventilation syndrome model is induced through non‐cell autonomous developmental mechanisms

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recommendations! Published in 2020 at "Brain Pathology"

DOI: 10.1111/bpa.12877

Abstract: Congenital central hypoventilation syndrome (CCHS) represents a rare genetic disorder usually caused by mutations in the homeodomain transcription factor PHOX2B. Some CCHS patients suffer mainly from deficiencies in CO2 and/or O2 respiratory chemoreflex, whereas other… read more here.

Keywords: murine; congenital central; visceral motor; non cell ... See more keywords

Non–cell-autonomous regulation of interneuron specification mediated by extracellular vesicles

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recommendations! Published in 2023 at "Science Advances"

DOI: 10.1126/sciadv.add8164

Abstract: Disruption in neurogenesis and neuronal migration can influence the assembly of cortical circuits, affecting the excitatory-inhibitory balance and resulting in neurodevelopmental and neuropsychiatric disorders. Using ventral cerebral organoids and dorsoventral cerebral assembloids with mutations in… read more here.

Keywords: extracellular vesicles; cell autonomous; autonomous regulation; non cell ... See more keywords