Cdc48Ufd1/Npl4 segregase removes mislocalized centromeric histone H3 variant CENP-A from non-centromeric chromatin.
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DOI: 10.1093/nar/gkac135
Abstract: Restricting the localization of CENP-A (Cse4 in Saccharomyces cerevisiae) to centromeres prevents chromosomal instability (CIN). Mislocalization of overexpressed CENP-A to non-centromeric chromatin contributes to CIN in budding and fission yeasts, flies, and humans. Overexpression and… read more here.
Keywords: centromeric chromatin; cenp; cdc48ufd1 npl4; non centromeric ... See more keywords