Array‐based profiling of the lymphoma cell DNA methylome does not unequivocally distinguish primary lymphomas of the central nervous system from non‐CNS diffuse large B‐cell lymphomas
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DOI: 10.1002/gcc.22687
Abstract: Primary lymphomas of the central nervous system (PCNSL) are diffuse large B‐cell lymphomas (DLBCLs) confined to the central nervous system (CNS). We here performed array‐based DNA methylation analyses of 26 PCNSL and 78 DLBCL and… read more here.
Keywords: nervous system; central nervous; cns; non cns ... See more keywords
Brain Penetration of Lorlatinib: Cumulative Incidences of CNS and Non-CNS Progression with Lorlatinib in Patients with Previously Treated ALK-Positive Non-Small-Cell Lung Cancer
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DOI: 10.1007/s11523-020-00702-4
Abstract: Background Lorlatinib is a potent, third-generation ALK/ROS1 tyrosine kinase inhibitor (TKI) designed to penetrate the blood–brain barrier. Objective We report the cumulative incidence of central nervous system (CNS) and non-CNS progression with lorlatinib in patients… read more here.
Keywords: progression; cns progression; cns non; non cns ... See more keywords
Cortical Morphometry and Its Relationship with Cognitive Functions in Children after non-CNS Cancer
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DOI: 10.1080/17518423.2021.1898059
Abstract: ABSTRACT Background: Childhood cancer survivors (Ccs) are at risk for cognitive late-effects, which might result from cortical alterations, even if cancer does not affect the brain. The study aimed to examine gray and white matter… read more here.
Keywords: cognitive functions; cortical morphometry; non cns; cancer ... See more keywords
Abstract A37: Unique gene fusions inform targeted therapeutic strategies across extremely rare, non-CNS pediatric solid tumors
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DOI: 10.1158/1538-7445.pedca19-a37
Abstract: Introduction: In children, approximately 7% of the non-CNS solid tumors include extremely rare histologies such as angiosarcomas and histiocytic neoplasms. While most recurrent histologies can be identified with a commonly occurring alteration or associated with… read more here.
Keywords: gene fusions; solid tumors; non cns; extremely rare ... See more keywords
Characterization of Extramedullary Disease in B-ALL and Response to CAR T-cell Therapy.
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DOI: 10.1182/bloodadvances.2021006035
Abstract: Chimeric antigen receptor (CAR) T-cells effectively eradicate medullary B-cell acute lymphoblastic leukemia (B-ALL) and can traffic to and clear central nervous system (CNS) involvement. CAR T-cell activity in non¬contral nervous system (CNS) extramedullary disease (EMD)… read more here.
Keywords: response; cns emd; car; non cns ... See more keywords