Engineered Fusion Enzyme‐Mediated Non‐Consecutive Cyclization‐Glycosylation Enables Heterologous Synthesis of Antifungal Enfumafungin
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DOI: 10.1002/advs.202507531
Abstract: Enfumafungin‐type antibiotics, represented by enfumafungin and fuscoatroside, constitute a distinct class of fungi‐derived fernane‐type triterpenoids renowned for their potent antifungal activity. Notably, ibrexafungerp, a semi‐chemically synthesized analogue of enfumafungin, has recently received approval as a… read more here.
Keywords: fusion; enfumafungin; biosynthesis; non consecutive ... See more keywords
Theta‐curves in proteins
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DOI: 10.1002/pro.5133
Abstract: We study and characterize the topology of connectivity circuits observed in natively folded protein structures whose coordinates are deposited in the Protein Data Bank (PDB). Polypeptide chains of some proteins naturally fold into unique knotted… read more here.
Keywords: consecutive amino; polypeptide chains; amino acids; non consecutive ... See more keywords
Non-consecutive enzyme interactions within TCA cycle supramolecular assembly regulate carbon-nitrogen metabolism
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DOI: 10.1038/s41467-024-49646-7
Abstract: Enzymes of the central metabolism tend to assemble into transient supramolecular complexes. However, the functional significance of the interactions, particularly between enzymes catalyzing non-consecutive reactions, remains unclear. Here, by co-localizing two non-consecutive enzymes of the… read more here.
Keywords: supramolecular; carbon nitrogen; metabolism; non consecutive ... See more keywords
Comparison of the 24 h Dietary Recall of Two Consecutive Days, Two Non-Consecutive Days, Three Consecutive Days, and Three Non-Consecutive Days for Estimating Dietary Intake of Chinese Adult
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DOI: 10.3390/nu14091960
Abstract: The specific forms of 24 h dietary recall used by national nutrition surveys differ, such as two non-consecutive days and three consecutive days. However, it is unclear which form of 24 h dietary recall is… read more here.
Keywords: days three; recall; three consecutive; non consecutive ... See more keywords