Non-conserved residues dictate dopamine transporter selectivity for the potent synthetic cathinone and psychostimulant MDPV
Sign Up to like & getrecommendations! Published in 2021 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2021.108820
Abstract: Clandestine chemists are currently exploiting the pyrrolidinophenone scaffold to develop new designer drugs that carry the risk of abuse and overdose. These drugs promote addiction through the rewarding effects of increased dopaminergic neurotransmission. 3,4-Methylenedioxypyrovalerone (MDPV)… read more here.
Keywords: non conserved; mdpv; dopamine transporter; conserved residues ... See more keywords
Comparison of coarsening behaviour in non-conserved and volume-conserved isotropic two-phase grain structures
Sign Up to like & getrecommendations! Published in 2018 at "Scripta Materialia"
DOI: 10.1016/j.scriptamat.2017.11.023
Abstract: Abstract Microstructure evolution in non-conserved and volume-conserved isotropic two-phase grain structures, with equal interfacial energy for all interfaces and equal volume fractions of the two-phases, is compared based on large-scale phase-field simulations. Two important observations… read more here.
Keywords: volume conserved; phase; conserved volume; non conserved ... See more keywords
In vivo functional analysis of non-conserved human lncRNAs associated with cardiometabolic traits
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-019-13688-z
Abstract: Unlike protein-coding genes, the majority of human long non-coding RNAs (lncRNAs) are considered non-conserved. Although lncRNAs have been shown to function in diverse pathophysiological processes in mice, it remains largely unknown whether human lncRNAs have… read more here.
Keywords: non conserved; cardiometabolic traits; human lncrnas; conserved human ... See more keywords
A conserved arginine with non‐conserved function is a key determinant of agonist selectivity in α7 nicotinic ACh receptors
Sign Up to like & getrecommendations! Published in 2021 at "British Journal of Pharmacology"
DOI: 10.1111/bph.15389
Abstract: The α7 and α4β2* (“*” denotes possibly assembly with another subunit) nicotinic acetylcholine receptors (nAChRs) are the most abundant nAChRs in the mammalian brain. These receptors are the most targeted nAChRs in drug discovery programmes… read more here.
Keywords: arginine non; conserved arginine; non conserved; function key ... See more keywords
Non-Conserved Amino Acid Residues Modulate the Thermodynamics of Zn(II) Binding to Classical ββα Zinc Finger Domains
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232314602
Abstract: Classical zinc fingers domains (ZFs) bind Zn(II) ion by a pair of cysteine and histidine residues to adopt a characteristic and stable ββα fold containing a small hydrophobic core. As a component of transcription factors,… read more here.
Keywords: classical zinc; structure; thermodynamics; zfs ... See more keywords
Conservation Study of Imprinted Genes in Maize Triparental Heterozygotic Kernels
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232315424
Abstract: Genomic imprinting is a classic epigenetic phenomenon related to the uniparental expression of genes. Imprinting variability exists in seeds and can contribute to observed parent-of-origin effects on seed development. Here, we conducted allelic expression of… read more here.
Keywords: expression; b73; mo17 added; non conserved ... See more keywords
Tsallis Holographic Dark Energy in f(G, T) Gravity
Sign Up to like & getrecommendations! Published in 2019 at "Symmetry"
DOI: 10.3390/sym11010092
Abstract: In this paper, we study the reconstruction paradigm for Tsallis holographic dark energy model using generalized Tsallis entropy conjecture with Hubble horizon in the framework of f ( G , T ) gravity (G and… read more here.
Keywords: energy; non conserved; dark energy; holographic dark ... See more keywords