The frequency of CpG and non-CpG methylation of Notch3 gene promoter determines its expression levels in breast cancer cells.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2019.111743
Abstract: Notch3 can act as a tumor suppressor in the breast cancer epithelial cells. Unfortunately, Notch3 expression is decreased or lost, especially in triple-negative breast cancer (TNBC) cells, and the reasons remain unclear. Here, we found… read more here.
Keywords: cpg methylation; non cpg; cpg; breast cancer ... See more keywords
Structural basis of water-mediated cis Watson–Crick/Hoogsteen base-pair formation in non-CpG methylation
Sign Up to like & getrecommendations! Published in 2024 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkae594
Abstract: Abstract Non-CpG methylation is associated with several cellular processes, especially neuronal development and cancer, while its effect on DNA structure remains unclear. We have determined the crystal structures of DNA duplexes containing -CGCCG- regions as… read more here.
Keywords: methylation; geometry; non cpg; base pair ... See more keywords
Functional Downregulation of PD-L1 and PD-L2 by CpG and non-CpG Oligonucleotides in Melanoma Cells
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DOI: 10.3390/cancers14194698
Abstract: Simple Summary Although metastatic melanoma is still not a curable disease, targeting of immunologically relevant checkpoints represents a turning point in the treatment. Particularly, targeting the interaction between PD-L1 and its referring receptor PD-1 with… read more here.
Keywords: tumor cells; cpg; non cpg; melanoma cells ... See more keywords
FZD7, Regulated by Non-CpG Methylation, Plays an Important Role in Immature Porcine Sertoli Cell Proliferation
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DOI: 10.3390/ijms24076179
Abstract: The regulatory role of non-CpG methylation in mammals has been important in whole-genome bisulfite sequencing. It has also been suggested that non-CpG methylation regulates gene expression to affect the development and health of mammals. However,… read more here.
Keywords: fzd7; cpg methylation; non cpg; proliferation ... See more keywords