Creation and resolution of non-B-DNA structural impediments during replication
Sign Up to like & getrecommendations! Published in 2022 at "Critical reviews in biochemistry and molecular biology"
DOI: 10.1080/10409238.2022.2121803
Abstract: Abstract During replication, folding of the DNA template into non-B-form secondary structures provides one of the most abundant impediments to the smooth progression of the replisome. The core replisome collaborates with multiple accessory factors to… read more here.
Keywords: replication; creation resolution; dna structural; resolution non ... See more keywords
NBBC: a non-B DNA burden explorer in cancer.
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic acids research"
DOI: 10.1093/nar/gkad379
Abstract: Alternate (non-B) DNA-forming structures, such as Z-DNA, G-quadruplex, triplex have demonstrated a potential role in cancer etiology. It has been found that non-B DNA-forming sequences can stimulate genetic instability in human cancer genomes, implicating them… read more here.
Keywords: burden; non dna; cancer; nbbc non ... See more keywords
ALU non-B-DNA conformations, flipons, binary codes and evolution
Sign Up to like & getrecommendations! Published in 2020 at "Royal Society Open Science"
DOI: 10.1098/rsos.200222
Abstract: ALUs contribute to genetic diversity by altering DNA's linear sequence through retrotransposition, recombination and repair. ALUs also have the potential to form alternative non-B-DNA conformations such as Z-DNA, triplexes and quadruplexes that alter the read-out… read more here.
Keywords: alu non; dna; dna conformations; non dna ... See more keywords
Long-read sequencing technology indicates genome-wide effects of non-B DNA on polymerization speed and error rate.
Sign Up to like & getrecommendations! Published in 2018 at "Genome research"
DOI: 10.1101/gr.241257.118
Abstract: DNA conformation may deviate from the classical B-form in ∼13% of the human genome. Non-B DNA regulates many cellular processes; however, its effects on DNA polymerization speed and accuracy have not been investigated genome-wide. Such… read more here.
Keywords: non dna; dna polymerization; polymerization; polymerization speed ... See more keywords