Outcome of T‐cell acute lymphoblastic leukemia/lymphoma: Focus on near‐ETP phenotype and differential impact of nelarabine
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DOI: 10.1002/ajh.26144
Abstract: Early T‐cell precursor acute lymphoblastic leukemia/lymphoma (ETP‐ALL/LBL) is characterized by a distinct immunophenotype (CD1a‐negative, CD8‐negative, CD5‐negative or weak‐positive read more here.
Keywords: near etp; etp lbl; non etp; etp ... See more keywords
Optimized outcome prediction of oncogenetic mutations in non-early T-cell precursor acute lymphoblastic leukemia.
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DOI: 10.1016/j.imbio.2022.152205
Abstract: BACKGROUND Early biomarkers allowing effective treatment stratification in adult T-cell acute lymphoblastic leukemia (T-ALL) patients remain elusive. MATERIALS AND METHODS The mutation spectrum of 116T-ALL adult patients enrolled in the Shanghai Institute of Hematology (SIH)-based… read more here.
Keywords: etp; non etp; hematology; acute lymphoblastic ... See more keywords
Cytogenetic and molecular characteristics and outcomes of adult patients with early T‐cell precursor acute lymphoblastic leukemia
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DOI: 10.1111/ejh.13883
Abstract: Early T‐cell precursor acute lymphoblastic leukemia (ETP‐ALL) is a recently identified high‐risk subgroup of T‐cell ALL in children. However, there have been conflicting reports and limited data have been reported in adult patients. We retrospectively… read more here.
Keywords: non etp; adult patients; etp; molecular characteristics ... See more keywords
In Silico Integration of Transcriptome and Interactome Predicts an ETP-ALL-Specific Transcriptional Footprint that Decodes its Developmental Propensity
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DOI: 10.3389/fcell.2022.899752
Abstract: Early T precursor acute lymphoblastic leukemia (ETP-ALL) exhibits poor clinical outcomes and high relapse rates following conventional chemotherapeutic protocols. Extensive developmental flexibility of the multipotent ETP-ALL blasts with considerable intra-population heterogeneity in terms of immunophenotype… read more here.
Keywords: non etp; etp; expression; lineage ... See more keywords