Small molecule-mediated co-assembly of amyloid-β oligomers reduces neurotoxicity through promoting non-fibrillar aggregation†
Sign Up to like & getrecommendations! Published in 2020 at "Chemical Science"
DOI: 10.1039/d0sc00392a
Abstract: Amyloid-β (Aβ) oligomers, particularly low molecular weight (LMW) oligomers, rather than fibrils, contribute very significantly to the onset and progression of Alzheimer's Disease (AD). However, due to the inherent heterogeneity and metastability of oligomers, most… read more here.
Keywords: mediated assembly; small molecule; non fibrillar; molecule mediated ... See more keywords
Isolation of infectious, non-fibrillar and oligomeric prions from a genetic prion disease
Sign Up to like & getrecommendations! Published in 2020 at "Brain"
DOI: 10.1093/brain/awaa078
Abstract: Gerstmann-Sträussler-Scheinker disease (GSS) is characterized by atypical N- and C-terminal cleaved protease-resistant PrPSc. Vanni et al. report that PrPSc oligomers purified from patients with GSS are authentic – but non-fibrillar – prions, thus uncovering the… read more here.
Keywords: isolation infectious; prion; non fibrillar; disease ... See more keywords