Influence of genetic and non-genetic factors on phenytoin-induced severe cutaneous adverse drug reactions
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Clinical Pharmacology"
DOI: 10.1007/s00228-017-2250-2
Abstract: PurposeThe purpose of this study was to investigate the association of genetic factors including variants in HLA-B and CYP2C genes and non-genetic factors with phenotype-specific phenytoin (PHT)-induced severe cutaneous adverse reactions (SCARs) in Thai patients.MethodsThirty-six… read more here.
Keywords: pht induced; genetic non; genetic factors; non genetic ... See more keywords
Redefining the Etiologic Landscape of Cerebellar Malformations.
Sign Up to like & getrecommendations! Published in 2019 at "American journal of human genetics"
DOI: 10.1016/j.ajhg.2019.07.019
Abstract: Cerebellar malformations are diverse congenital anomalies frequently associated with developmental disability. Although genetic and prenatal non-genetic causes have been described, no systematic analysis has been performed. Here, we present a large-exome sequencing study of Dandy-Walker… read more here.
Keywords: landscape cerebellar; non genetic; redefining etiologic; cerebellar malformations ... See more keywords
Body condition score, parity, shelter cleanliness and male proximity: Highly associated non-genetic factors with post-partum anestrus in Murrah buffalo in field conditions.
Sign Up to like & getrecommendations! Published in 2020 at "Animal reproduction science"
DOI: 10.1016/j.anireprosci.2020.106282
Abstract: Postpartum anestrus (PPA) is a major reproductive problem in buffalo. Although both genetic and non-genetic factors influence the incidence of PPA, identifying associated non-genetic factors would be helpful for effective management of this problem. No… read more here.
Keywords: score; murrah buffalo; genetic factors; non genetic ... See more keywords
The Repertoire of Serous Ovarian Cancer Non-genetic Heterogeneity Revealed by Single-Cell Sequencing of Normal Fallopian Tube Epithelial Cells.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer cell"
DOI: 10.1016/j.ccell.2020.01.003
Abstract: The inter-differentiation between cell states promotes cancer cell survival under stress and fosters non-genetic heterogeneity (NGH). NGH is, therefore, a surrogate of tumor resilience but its quantification is confounded by genetic heterogeneity. Here we show that… read more here.
Keywords: genetic heterogeneity; non genetic; ovarian cancer; cancer ... See more keywords
Memory Sequencing Reveals Heritable Single-Cell Gene Expression Programs Associated with Distinct Cellular Behaviors
Sign Up to like & getrecommendations! Published in 2020 at "Cell"
DOI: 10.1016/j.cell.2020.07.003
Abstract: Non-genetic factors can cause individual cells to fluctuate substantially in gene expression levels over time. It remains unclear whether these fluctuations can persist for much longer than the time of one cell division. Current methods… read more here.
Keywords: gene expression; non genetic; gene; cell ... See more keywords
Profiling the Non-genetic Origins of Cancer Drug Resistance with a Single-Cell Functional Genomics Approach Using Predictive Cell Dynamics.
Sign Up to like & getrecommendations! Published in 2020 at "Cell systems"
DOI: 10.1016/j.cels.2020.08.019
Abstract: Non-genetic heterogeneity observed in clonal cell populations is an immediate cause of drug resistance that remains challenging to profile because of its transient nature. Here, we coupled three single-cell technologies to link the predicted drug… read more here.
Keywords: drug; non genetic; drug resistance; cell ... See more keywords
Diverse Non-genetic, Allele-Specific Expression Effects Shape Genetic Architecture at the Cellular Level in the Mammalian Brain
Sign Up to like & getrecommendations! Published in 2017 at "Neuron"
DOI: 10.1016/j.neuron.2017.01.033
Abstract: Interactions between genetic and epigenetic effects shape brain function, behavior, and the risk for mental illness. Random X inactivation and genomic imprinting are epigenetic allelic effects that are well known to influence genetic architecture and… read more here.
Keywords: effects shape; non genetic; allelic effects; diverse non ... See more keywords
Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity.
Sign Up to like & getrecommendations! Published in 2017 at "Cell stem cell"
DOI: 10.1016/j.stem.2016.11.005
Abstract: Variability in induced pluripotent stem cell (iPSC) lines remains a concern for disease modeling and regenerative medicine. We have used RNA-sequencing analysis and linear mixed models to examine the sources of gene expression variability in… read more here.
Keywords: non genetic; variability; expression; ipsc lines ... See more keywords
CYP2B6 allelic variants and non-genetic factors influence CYP2B6 enzyme function
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-022-07022-9
Abstract: Human CYP2B6 enzyme although constitutes relatively low proportion (1–4%) of hepatic cytochrome P450 content, it is the major catalyst of metabolism of several clinically important drugs (efavirenz, cyclophosphamide, bupropion, methadone). High interindividual variability in CYP2B6… read more here.
Keywords: function; cyp2b6; genetic factors; cyp2b6 enzyme ... See more keywords
The impact of non-genetic heterogeneity on cancer cell death
Sign Up to like & getrecommendations! Published in 2018 at "Critical Reviews in Biochemistry and Molecular Biology"
DOI: 10.1080/10409238.2017.1412395
Abstract: Abstract The goal of cancer chemotherapy is to induce homogeneous cell death within the population of targeted cancer cells. However, no two cells are exactly alike at the molecular level, and sensitivity to drug-induced cell… read more here.
Keywords: non genetic; drug; cell death; cancer ... See more keywords
The body weight heritability and the effect of non-genetic factors on the body measurement traits in Qinchuan cattle.
Sign Up to like & getrecommendations! Published in 2022 at "Animal biotechnology"
DOI: 10.1080/10495398.2022.2154222
Abstract: This study aimed to understand the influence of the non-genetic factors that include breeding year, season, and sex of growth and development traits of Qinchuan cattle and to estimate the heritability of body weight at… read more here.
Keywords: qinchuan cattle; heritability; body weight; genetic factors ... See more keywords