Mesenchyme-derived factors enhance preneoplastic growth by non-genotoxic carcinogens in rat liver
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DOI: 10.1007/s00204-017-2080-0
Abstract: Many frequently prescribed drugs are non-genotoxic carcinogens (NGC) in rodent liver. Their mode of action and health risks for humans remain to be elucidated. Here, we investigated the impact of two model NGC, the anti-epileptic… read more here.
Keywords: growth; non genotoxic; genotoxic carcinogens; rat liver ... See more keywords
Mitochondrial relocation of a common synthetic antibiotic: A non-genotoxic approach to cancer therapy.
Sign Up to like & getrecommendations! Published in 2020 at "Chem"
DOI: 10.1016/j.chempr.2020.03.004
Abstract: Tumor recurrence as a result of therapy-induced nuclear DNA lesions is a major issue in cancer treatment. Currently, only a few examples of potentially non-genotoxic drugs have been reported. Mitochondrial re-localization of ciprofloxacin, one of… read more here.
Keywords: therapy; mitochondrial relocation; non genotoxic; approach ... See more keywords
Fe3O4 coated guargum nanoparticles as non-genotoxic materials for biological application.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.09.144
Abstract: The current study aims to check various behavioural, developmental, cytotoxic, and genotoxic effects of Fe3O4-GG nanocomposite (GGNCs) on Drosophila melanogaster. Fe3O4 nanoparticles were prepared by the chemical co-precipitation method and cross-linked with guargum nanoparticles to… read more here.
Keywords: coated guargum; non genotoxic; fe3o4 coated; nanoparticles non ... See more keywords
Use of early phenotypic in vivo markers to assess human relevance of an unusual rodent non-genotoxic carcinogen in vitro.
Sign Up to like & getrecommendations! Published in 2017 at "Toxicology"
DOI: 10.1016/j.tox.2017.01.018
Abstract: Foci of altered hepatocytes (FAH) are considered putative, pre-neoplastic lesions that can occur spontaneously in aging rodents, but can also be induced by chemicals or drugs. Progression of FAH to hepatocellular neoplasms has been reported… read more here.
Keywords: genotoxic carcinogen; relevance; non genotoxic; human relevance ... See more keywords
Stem cell proliferation patterns as an alternative for in vivo prediction and discrimination of carcinogenic compounds
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep45616
Abstract: One of the major challenges in the development of alternative carcinogenicity assays is the prediction of non-genotoxic carcinogens. The variety of non-genotoxic cancer pathways complicates the search for reliable parameters expressing their carcinogenicity. As non-genotoxic… read more here.
Keywords: non genotoxic; proliferation; stem cell; genotoxic ... See more keywords
Differential responses on energy metabolic pathway reprogramming between genotoxic and non-genotoxic hepatocarcinogens in rat liver cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Toxicologic Pathology"
DOI: 10.1293/tox.2019-0048
Abstract: To clarify difference in the responses on the reprogramming of metabolism toward carcinogenesis between genotoxic and non-genotoxic hepatocarcinogens in the liver, rats were repeatedly administered genotoxic hepatocarcinogens (N-nitrosodiethylamine, aflatoxin B1, N-nitrosopyrrolidine, or carbadox) or non-genotoxic… read more here.
Keywords: genotoxic hepatocarcinogens; days suggesting; non genotoxic; genotoxic non ... See more keywords