Abstract IA21: Interrogating cancer drivers and dependencies using non-germline mouse models
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.mousemodels17-ia21
Abstract: Cancer is a heterogeneous disease involving various genetic and epigenetic alterations that initiate and maintain the disease. Our laboratory is interested in understanding how such alterations contribute to tumorigenesis, alter treatment response, and create vulnerabilities… read more here.
Keywords: mouse models; non germline; germline mouse; cancer ... See more keywords
Olaparib maintenance monotherapy for non-germline BRCA1/2-mutated (non-gBRCAm) platinum-sensitive relapsed ovarian cancer (PSR OC) patients (pts): Phase IIIb OPINION interim analysis.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.15_suppl.6057
Abstract: 6057Background: In the Phase II Study 19 trial (NCT00753545; Ledermann et al. Lancet Oncol 2014), maintenance olaparib improved progression-free survival (PFS) vs placebo in PSR OC pts, including t... read more here.
Keywords: maintenance monotherapy; maintenance; non germline; psr ... See more keywords