Sensing context: Inhibitory receptors on nonâhematopoietic cells
Sign Up to like & getrecommendations! Published in 2023 at "European Journal of Immunology"
DOI: 10.1002/eji.202250306
Abstract: Similar to immune cells, nonâhematopoietic cells recognize microbial and endogenous threats. Their response to these stimuli is dependent on the environmental context. For example, intact intestinal epithelium expresses pattern recognition receptors (PRRs) but should tolerate… read more here.
Keywords: receptors non; hematopoietic cells; inhibitory receptors; non hematopoietic ... See more keywords
Metastatic non-Hematopoietic Neoplasms to the Breast: A Study of 238 Cases.
Sign Up to like & getrecommendations! Published in 2022 at "Human pathology"
DOI: 10.1016/j.humpath.2022.04.009
Abstract: AIMS The aim of this study was to review the clinicopathologic characteristics of metastatic non-hematopoietic malignancies to the breast, in order to identify salient features for practicing pathologist that are useful in distinguishing metastatic lesions… read more here.
Keywords: metastatic non; 238 cases; non hematopoietic; study ... See more keywords
Non-Hematopoietic Lymphoid Stromal Cells Prime Alloreactive CD4+ T Cells in Acute Graft-Versus-Host Disease
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood-2019-125665
Abstract: Allogeneic T cell priming is considered as an essential event determining the outcome of allogeneic hematopoietic stem cell transplantation (allo-HCT), ideally triggering anti-leukemic responses (GvL effect) or, at worst, causing life-threatening acute graft-versus-host disease (aGvHD).… read more here.
Keywords: allo hct; cd4 cells; non hematopoietic; alloreactive cd4 ... See more keywords
CD38 a biomarker and therapeutic target in non-hematopoietic tumors.
Sign Up to like & getrecommendations! Published in 2022 at "Biomarkers in medicine"
DOI: 10.2217/bmm-2021-0575
Abstract: The type II transmembrane glycoprotein CD38 has recently been implicated in regulating metabolism and the pathogenesis of multiple conditions, including aging, inflammation and cancer. CD38 is overexpressed in several tumor cells and microenvironment tumoral cells,… read more here.
Keywords: therapeutic target; cd38 biomarker; biomarker therapeutic; target non ... See more keywords
A small erythropoietin derived non-hematopoietic peptide reduces cardiac inflammation, attenuates age associated declines in heart function and prolongs healthspan
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.1096887
Abstract: Background Aging is associated with increased levels of reactive oxygen species and inflammation that disrupt proteostasis and mitochondrial function and leads to organism-wide frailty later in life. ARA290 (cibinetide), an 11-aa non-hematopoietic peptide sequence within… read more here.
Keywords: inflammation; hematopoietic peptide; age associated; age ... See more keywords
Non-hematopoietic Control of Peripheral Tissue T Cell Responses: Implications for Solid Tumors
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.02662
Abstract: In response to pathological challenge, the host generates rapid, protective adaptive immune responses while simultaneously maintaining tolerance to self and limiting immune pathology. Peripheral tissues (e.g., skin, gut, lung) are simultaneously the first site of… read more here.
Keywords: non hematopoietic; peripheral tissue; hematopoietic control; tissue ... See more keywords