AT1R-Ab: A New Player in Pediatric Heart Transplant AMR?
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Heart and Lung Transplantation"
DOI: 10.1016/j.healun.2021.01.1820
Abstract: Purpose Angiotensin II type 1 receptor antibodies (AT1R-Ab) are associated with non-human leukocyte antigen (HLA) mediated antibody mediated rejection (AMR) and graft failure in adult renal transplantation. They can be stimulated by ventricular assist device… read more here.
Keywords: heart; amr; non hla; hla mediated ... See more keywords
Non HLA Antibodies in Serum Prior to the Onset of Chronic Lung Allograft Dysfunction
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Heart and Lung Transplantation"
DOI: 10.1016/j.healun.2021.01.465
Abstract: Purpose Non-human leukocyte antigen (HLA) antibodies have been associated with chronic lung allograft dysfunction (CLAD). Whether they predate CLAD is unclear. We hypothesized that patients destined to develop CLAD might develop non-HLA antibodies prior to… read more here.
Keywords: chronic lung; clad; non hla; hla antibodies ... See more keywords
Identification of non-HLA genes associated with development of islet autoimmunity and type 1 diabetes in the prospective TEDDY cohort.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of autoimmunity"
DOI: 10.1016/j.jaut.2017.12.008
Abstract: Traditional linkage analysis and genome-wide association studies have identified HLA and a number of non-HLA genes as genetic factors for islet autoimmunity (IA) and type 1 diabetes (T1D). However, the relative risk associated with previously… read more here.
Keywords: risk; non hla; hla genes; islet ... See more keywords
The emerging field of non-HLA-antibodies in transplant medicine and beyond.
Sign Up to like & getrecommendations! Published in 2021 at "Kidney international"
DOI: 10.1016/j.kint.2021.04.044
Abstract: The major medical advances in our knowledge of the human leukocyte antigen (HLA) system have allowed to uncover several gaps in our understanding of alloimmunity. Although the non-HLA system has long sparked the interest of… read more here.
Keywords: medicine; emerging field; immunity; non hla ... See more keywords
Nonhuman leukocyte antigen antibodies that have impact in the heart transplant patient.
Sign Up to like & getrecommendations! Published in 2019 at "Current Opinion in Organ Transplantation"
DOI: 10.1097/mot.0000000000000642
Abstract: PURPOSE OF REVIEW Despite human leukocyte antigen (HLA) matching and monitoring for donor-specific HLA antibodies, antibody-mediated rejection and chronic rejection in the form of allograft vasculopathy and chronic graft dysfunction continue to occur. There has… read more here.
Keywords: nonhuman leukocyte; heart; leukocyte antigen; non hla ... See more keywords
Non-HLA Antibodies Impact on C4d Staining, Stellate Cell Activation and Fibrosis in Liver Allografts
Sign Up to like & getrecommendations! Published in 2017 at "Transplantation"
DOI: 10.1097/tp.0000000000001853
Abstract: Background Recent data have shown an increased risk for rejection, fibrosis progression, and death in liver transplantation (LT) recipients with preformed or de novo HLA donor-specific alloantibodies (DSA). However, the role of non-HLA autoantibodies and… read more here.
Keywords: hla dsa; non hla; hla; hla autoantibodies ... See more keywords
Non-HLA Genetic Factors and Their Influence on Heart Transplant Outcomes: A Systematic Review
Sign Up to like & getrecommendations! Published in 2019 at "Transplantation Direct"
DOI: 10.1097/txd.0000000000000859
Abstract: Background Improvement of immunosuppressive therapies and surgical techniques has increased the survival rate after heart transplantation. Nevertheless, a large number of patients still experience complications, such as allograft rejection, vasculopathy, kidney dysfunction, and diabetes in… read more here.
Keywords: heart; hla genetic; transplantation; non hla ... See more keywords
Hyperacute Antibody-mediated Rejection Associated With Red Blood Cell Antibodies
Sign Up to like & getrecommendations! Published in 2019 at "Transplantation Direct"
DOI: 10.1097/txd.0000000000000925
Abstract: T pathogenic role of non-HLA antibodies in antibodymediated rejection (AMR) has been increasingly recognized, with inclusion in the Banff 2017 classification.1 While several non-HLA antibodies have been implicated, it is clear there are additional uncharacterized… read more here.
Keywords: blood; hyperacute antibody; rejection; red blood ... See more keywords
Antibodies against ARHGDIB are associated with long‐term kidney graft loss
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Transplantation"
DOI: 10.1111/ajt.15493
Abstract: The clinical significance of non‐HLA antibodies on renal allograft survival is a matter of debate, due to differences in reported results and lack of large‐scale studies incorporating analysis of multiple non‐HLA antibodies simultaneously. We developed… read more here.
Keywords: non hla; graft loss; hla antibodies; kidney ... See more keywords
Rejection in the setting of non‐HLA antibody: New tools for navigating bench to bedside
Sign Up to like & getrecommendations! Published in 2020 at "American Journal of Transplantation"
DOI: 10.1111/ajt.15975
Abstract: There is a growing body of literature linking non-HLA antibodies to acute and chronic allograft injury across all transplanted organ types (1). Even more striking is the injury potential observed when non-HLA antibodies are detected… read more here.
Keywords: non hla; rejection setting; injury; hla antibodies ... See more keywords
Impact and production of Non‐HLA‐specific antibodies in solid organ transplantation
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Immunogenetics"
DOI: 10.1111/iji.12494
Abstract: Organ transplantation is an effective way to treat end‐stage organ disease. Extending the graft survival is one of the major goals in the modern era of organ transplantation. However, long‐term graft survival has not significantly… read more here.
Keywords: non hla; organ transplantation; hla specific; transplantation ... See more keywords