SAR exploration of the non‐imidazole histamine H3 receptor ligand ZEL‐H16 reveals potent inverse agonism
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DOI: 10.1002/ardp.202200451
Abstract: Histamine H3 receptor (H3R) agonists without an imidazole moiety remain very scarce. Of these, ZEL‐H16 (1) has been reported previously as a high‐affinity non‐imidazole H3R (partial) agonist. Our structure‐activity relationship analysis using derivatives of 1… read more here.
Keywords: inverse agonism; zel h16; agonism; non imidazole ... See more keywords